DegronMD

Uniprot ID: Q7Z333

Source protein: Probable helicase senataxin

Source gene: SETX

Class: DEG_APCC_DBOX_1

Location: 1537:1545

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8627

ASA_SCORE: 88.1

COIL: 0.7432

CONS_SCORE: 0.2817

DSS_SCORE: 0.3949

HELIX: 0.1961

FCONS_SCORE: 1.0417

RIG_SCORE: 0.7199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1553Y	TCGA-A5-A0G2	UCEC	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	0.1111
p.D1553Y	DO41235	UCEC	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.1111
p.K1548E	TCGA-AX-A06F	UCEC	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	0.3611
p.K1548E	DO41752	UCEC	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.3611
p.S1545N	TCGA-BH-A0HF	BRCA	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	0.5958
p.S1545N	DO1749	BRCA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.5958
p.D1527Y	TCGA-BK-A6W3	UCEC	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	0.0556
p.D1527Y	DO7801	COAD	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.0556
p.D1527Y	DO50076	UCEC	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.0556
p.R1538Q	TCGA-DU-7013	LGG	TCGA	SRPQLESLS	DEG_APCC_DBOX_1	0.7329
p.R1538Q	DO22217	LGG	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.7329
p.R1538Q	SIDM00363	Acute Myeloid Leukemia	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	0.7329
p.R1538Q	ACH-000770	Leukemia	CCLE	SRPQLESLS	DEG_APCC_DBOX_1	0.7329
p.R1538Q	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	SRPQLESLS	DEG_APCC_DBOX_1	0.7329
p.C1554G	DO222492	COCA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.0833
p.C1554G	SIDM01020	Plasma Cell Myeloma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	0.0833
p.C1554G	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	0.0833
p.C1554G	SIDM00928	Breast Carcinoma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	0.0833
p.C1554G	SIDM01114	Non-Cancerous	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	0.0833
p.C1554G	SIDM00100	Mesothelioma	GDSC	SRPQLESLS	DEG_APCC_DBOX_1	0.0833
p.S1535F	DO220851	MELA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.2778
p.D1553N	DO232761	PBCA	ICGC	SRPQLESLS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z333	Probable helicase senataxin	DEG_APCC_DBOX_1	1537:1545	SRPQLESLS	APC,CDC20,FZR1	0.8627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons