DegronMD

Uniprot ID: Q7Z333

Source protein: Probable helicase senataxin

Source gene: SETX

Class: DEG_SCF_TRCP1_1

Location: 2496:2502

E3 ligase: BTRC

DEGRON score: 0.9423

ASA_SCORE: 86.5857

COIL: 0.8467

CONS_SCORE: 0.2574

DSS_SCORE: 0.4587

HELIX: 0.1337

FCONS_SCORE: 1.0574

RIG_SCORE: 0.6834

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2500S	TCGA-17-Z062	LUAD	TCGA	DSGFAKT	DEG_SCF_TRCP1_1	0.6477
p.L2495P	TCGA-60-2723	LUSC	TCGA	DSGFAKT	DEG_SCF_TRCP1_1	0.3056
p.T2490N	DO44216	BRCA	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	0.1667
p.L2509M	DO229041	LICA	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	0.1389
p.M2512I	DO28923	OV	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	0.0556
p.D2505H	DO223272	SARC	ICGC	DSGFAKT	DEG_SCF_TRCP1_1	0.25
p.K2501N	SIDM00193	Colorectal Carcinoma	GDSC	DSGFAKT	DEG_SCF_TRCP1_1	0.5806
p.K2501N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGFAKT	DEG_SCF_TRCP1_1	0.5806
p.K2501N	SNU-81	large_intestine	COSMIC	DSGFAKT	DEG_SCF_TRCP1_1	0.5806
p.S2497N	SIDM00842	Colorectal Carcinoma	GDSC	DSGFAKT	DEG_SCF_TRCP1_1	0.7069
p.S2497N	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	DSGFAKT	DEG_SCF_TRCP1_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z333	Probable helicase senataxin	DEG_SCF_TRCP1_1	2496:2502	DSGFAKT	BTRC	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons