DegronMD

Uniprot ID: Q7Z333

Source protein: Probable helicase senataxin

Source gene: SETX

Class: LIG_APCC_ABBA_1

Location: 896:901

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9125

ASA_SCORE: 63.5833

COIL: 0.4763

CONS_SCORE: 0.2041

DSS_SCORE: 0.4046

HELIX: 0.2438

FCONS_SCORE: 1.0434

RIG_SCORE: 0.8078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P898H	TCGA-49-6761	LUAD	TCGA	LIPFTE	LIG_APCC_ABBA_1	0.7694
p.P898H	DO24566	LUAD	ICGC	LIPFTE	LIG_APCC_ABBA_1	0.7694
p.E901D	TCGA-AP-A1DV	UCEC	TCGA	LIPFTE	LIG_APCC_ABBA_1	0.5647
p.E901D	DO43186	UCEC	ICGC	LIPFTE	LIG_APCC_ABBA_1	0.5647
p.G893C	TCGA-D3-A1QA	SKCM	TCGA	LIPFTE	LIG_APCC_ABBA_1	0.25
p.G893C	DO231672	LINC	ICGC	LIPFTE	LIG_APCC_ABBA_1	0.25
p.G893C	DO47469	SKCM	ICGC	LIPFTE	LIG_APCC_ABBA_1	0.25
p.K909N	TCGA-EO-A3AY	UCEC	TCGA	LIPFTE	LIG_APCC_ABBA_1	0.2222
p.K909N	DO43202	UCEC	ICGC	LIPFTE	LIG_APCC_ABBA_1	0.2222
p.G893A	DO232933	PEME	ICGC	LIPFTE	LIG_APCC_ABBA_1	0.25
p.P898S	DO229456	SKCA	ICGC	LIPFTE	LIG_APCC_ABBA_1	0.6752
p.V891A	SIDM00493	Other Solid Cancers	GDSC	LIPFTE	LIG_APCC_ABBA_1	0.1944
p.K908N	SIDM01588	Endometrial Carcinoma	GDSC	LIPFTE	LIG_APCC_ABBA_1	0.5833
p.K908N	ACH-000993	Endometrial/Uterine Cancer	CCLE	LIPFTE	LIG_APCC_ABBA_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z333	Probable helicase senataxin	LIG_APCC_ABBA_1	896:901	LIPFTE	APC,CDC20,FZR1	0.9125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons