DegronMD - P28702(RXRB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R81Q	TCGA-AA-3984	COAD	TCGA	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.3056
p.R81Q	TCGA-AA-3984	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.2778
p.R81Q	DO9002	COAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.3056
p.R81Q	DO9002	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.2778
p.D75N	TCGA-F7-A624	HNSC	TCGA	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.6932
p.D75N	DO44440	HNSC	ICGC	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.6932
p.S144C	DO48413	BLCA	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1944
p.R135C	DO617	BLCA	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.8301
p.I149S	DO6320	CESC	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.I66F	DO9860	COAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.0833
p.G89R	DO234455	ESAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.0833
p.G89R	DO234455	ESAD	ICGC	PDSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.2778
p.G128V	DO23038	LIHC	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.G78D	DO228138	PBCA	ICGC	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.7198
p.R138H	DO219410	PRAD	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.8244
p.D140Y	DO36394	READ	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.3056
p.R138S	DO37539	SKCM	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7427
p.K130N	DO47386	SKCM	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1944
p.G78A	DO222342	STAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.754
p.G78A	DO42977	UCEC	ICGC	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.754
p.P146L	DO229195	THCA	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1389
p.P97L	DO42977	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.0556
p.F132S	DO41584	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.25
p.P90S	ACH-000987	Skin Cancer	CCLE	DSGRDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.0556
p.P90S	ACH-000987	Skin Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.25
p.P143T	JHOS-2	ovary	COSMIC	VISSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222

Kaplan plot for RXRB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RXRB

UniProt ID: P28702

Entrez ID: 6257

Protein name: Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RXRB in