DegronMD

Uniprot ID: P28702

Source protein: Retinoic acid receptor RXR-beta

Source gene: RXRB

Class: DEG_SPOP_SBC_1

Location: 135:139

E3 ligase: SPOP

DEGRON score: 0.988

ASA_SCORE: 53.66

COIL: 0.7558

CONS_SCORE: 0.5747

DSS_SCORE: 0.6071

HELIX: 0.0512

FCONS_SCORE: 0.8837

RIG_SCORE: 0.5944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S144C	DO48413	BLCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.1944
p.R135C	DO617	BLCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.8301
p.I149S	DO6320	CESC	ICGC	VISSS	DEG_SPOP_SBC_1	0.0556
p.G128V	DO23038	LIHC	ICGC	VISSS	DEG_SPOP_SBC_1	0.1389
p.R138H	DO219410	PRAD	ICGC	VISSS	DEG_SPOP_SBC_1	0.8244
p.D140Y	DO36394	READ	ICGC	VISSS	DEG_SPOP_SBC_1	0.3056
p.R138S	DO37539	SKCM	ICGC	VISSS	DEG_SPOP_SBC_1	0.7427
p.K130N	DO47386	SKCM	ICGC	VISSS	DEG_SPOP_SBC_1	0.1944
p.P146L	DO229195	THCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.1389
p.F132S	DO41584	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.25
p.P143T	JHOS-2	ovary	COSMIC	VISSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	135:139	VISSS	SPOP	0.988	More...
P29590	Protein PML	DEG_SPOP_SBC_1	558:562	VISSS	SPOP	0.999	More...
Q7RTS7	Keratin, type II cytoskeletal 74	DEG_SPOP_SBC_1	465:469	VISSS	SPOP	0.5653	More...
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	12:16	VISSS	SPOP	0.6073	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_SPOP_SBC_1	446:450	VISSS	SPOP	0.9985	More...
Q8N128	Protein FAM177A1	DEG_SPOP_SBC_1	182:186	VISSS	SPOP	0.9894	More...
Q8TF20	Zinc finger protein 721	DEG_SPOP_SBC_1	245:249	VISSS	SPOP	0.7681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons