DegronMD

Uniprot ID: Q8TF20

Source protein: Zinc finger protein 721

Source gene: ZNF721

Class: DEG_SPOP_SBC_1

Location: 245:249

E3 ligase: SPOP

DEGRON score: 0.7681

ASA_SCORE: 56

COIL: 0.6698

CONS_SCORE: 0.4686

DSS_SCORE: 0.25

HELIX: 0.0878

FCONS_SCORE: 0.7581

RIG_SCORE: 0.7241

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C251Y	SIDM01966	Colorectal Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.7222
p.G245E	SIDM00712	Non-Cancerous	GDSC	VISSS	DEG_SPOP_SBC_1	0.7199
p.G245E	SIDM00713	Mesothelioma	GDSC	VISSS	DEG_SPOP_SBC_1	0.7199
p.G245E	ACH-002367	Non-Cancerous	CCLE	VISSS	DEG_SPOP_SBC_1	0.7199
p.E246D	TCGA-06-0129	GBM	TCGA	VISSS	DEG_SPOP_SBC_1	0.6758
p.E246D	DO11537	GBM	ICGC	VISSS	DEG_SPOP_SBC_1	0.6758
p.E246D	SIDM00118	Colorectal Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.6758
p.E246D	ACH-001081	Colon/Colorectal Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	0.6758
p.E246D	HCC2998	large_intestine	COSMIC	VISSS	DEG_SPOP_SBC_1	0.6758
p.C254Y	TCGA-DI-A1BU	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.6389
p.C254Y	DO42023	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.6389
p.E240D	TCGA-B5-A0JY	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.3056
p.E240D	DO43041	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.3056
p.E240K	DO229052	LICA	ICGC	VISSS	DEG_SPOP_SBC_1	0.3056
p.H243Y	DO222395	MELA	ICGC	VISSS	DEG_SPOP_SBC_1	0.2778
p.K241N	TCGA-BS-A0UF	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.2222
p.K241N	DO41488	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.2222
p.V257A	TCGA-FI-A2D5	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.1111
p.V257A	DO233855	GACA	ICGC	VISSS	DEG_SPOP_SBC_1	0.1111
p.V257A	DO41331	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	12:16	VISSS	SPOP	0.6073	More...
Q7RTS7	Keratin, type II cytoskeletal 74	DEG_SPOP_SBC_1	465:469	VISSS	SPOP	0.5653	More...
Q8N128	Protein FAM177A1	DEG_SPOP_SBC_1	182:186	VISSS	SPOP	0.9894	More...
P29590	Protein PML	DEG_SPOP_SBC_1	558:562	VISSS	SPOP	0.999	More...
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	135:139	VISSS	SPOP	0.988	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_SPOP_SBC_1	446:450	VISSS	SPOP	0.9985	More...
Q8TF20	Zinc finger protein 721	DEG_SPOP_SBC_1	245:249	VISSS	SPOP	0.7681	More...

Showing 1 to 7 of 7 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons