DegronMD - Q7RTS7(KRT74)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V465I	TCGA-19-1790	GBM	TCGA	VISSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7076
p.V465I	DO12328	GBM	ICGC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7076
p.P476H	TCGA-AA-3663	COAD	TCGA	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.P476H	DO9346	COAD	ICGC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.V465F	TCGA-CG-4442	STAD	TCGA	VISSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7068
p.V465F	DO38380	STAD	ICGC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7068
p.S459F	TCGA-CV-7568	HNSC	TCGA	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.S459F	DO14160	HNSC	ICGC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.H474Q	DO229028	LICA	ICGC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1944
p.S470N	DO50970	LICA	ICGC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.3056
p.E456V	DO231724	LINC	ICGC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.P476S	SIDM00683	Prostate Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.P476S	SIDM00948	Burkitt's Lymphoma	GDSC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.P476S	SIDM00261	Ewing's Sarcoma	GDSC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.H475R	SIDM01088	Endometrial Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.H475R	ACH-000965	Endometrial/Uterine Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.H475R	RL95-2	endometrium	COSMIC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.S470I	SIDM00980	Gastric Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.3056
p.H474Y	SIDM01609	Endometrial Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1944
p.H474Y	ACH-000972	Endometrial/Uterine Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1944
p.G462D	LU-165	lung	COSMIC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.25
p.E463G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VISSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2778

Kaplan plot for KRT74 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT74

UniProt ID: Q7RTS7

Entrez ID: 121391

Protein name: Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT74 in