DegronMD

Uniprot ID: Q7RTS7

Source protein: Keratin, type II cytoskeletal 74

Source gene: KRT74

Class: DEG_SPOP_SBC_1

Location: 465:469

E3 ligase: SPOP

DEGRON score: 0.5653

ASA_SCORE: 58.4

COIL: 0.5078

CONS_SCORE: 0.4497

DSS_SCORE: 0.3761

HELIX: 0.0114

FCONS_SCORE: 1.045

RIG_SCORE: 0.6789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V465I	TCGA-19-1790	GBM	TCGA	VISSS	DEG_SPOP_SBC_1	0.7076
p.V465I	DO12328	GBM	ICGC	VISSS	DEG_SPOP_SBC_1	0.7076
p.P476H	TCGA-AA-3663	COAD	TCGA	VISSS	DEG_SPOP_SBC_1	0.1389
p.P476H	DO9346	COAD	ICGC	VISSS	DEG_SPOP_SBC_1	0.1389
p.V465F	TCGA-CG-4442	STAD	TCGA	VISSS	DEG_SPOP_SBC_1	0.7068
p.V465F	DO38380	STAD	ICGC	VISSS	DEG_SPOP_SBC_1	0.7068
p.S459F	TCGA-CV-7568	HNSC	TCGA	VISSS	DEG_SPOP_SBC_1	0.1667
p.S459F	DO14160	HNSC	ICGC	VISSS	DEG_SPOP_SBC_1	0.1667
p.H474Q	DO229028	LICA	ICGC	VISSS	DEG_SPOP_SBC_1	0.1944
p.S470N	DO50970	LICA	ICGC	VISSS	DEG_SPOP_SBC_1	0.3056
p.E456V	DO231724	LINC	ICGC	VISSS	DEG_SPOP_SBC_1	0.0833
p.P476S	SIDM00683	Prostate Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.1389
p.P476S	SIDM00948	Burkitt's Lymphoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.1389
p.P476S	SIDM00261	Ewing's Sarcoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.1389
p.H475R	SIDM01088	Endometrial Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.1667
p.H475R	ACH-000965	Endometrial/Uterine Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	0.1667
p.H475R	RL95-2	endometrium	COSMIC	VISSS	DEG_SPOP_SBC_1	0.1667
p.S470I	SIDM00980	Gastric Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.3056
p.H474Y	SIDM01609	Endometrial Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.1944
p.H474Y	ACH-000972	Endometrial/Uterine Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	0.1944
p.G462D	LU-165	lung	COSMIC	VISSS	DEG_SPOP_SBC_1	0.25
p.E463G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VISSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	135:139	VISSS	SPOP	0.988	More...
P29590	Protein PML	DEG_SPOP_SBC_1	558:562	VISSS	SPOP	0.999	More...
Q7RTS7	Keratin, type II cytoskeletal 74	DEG_SPOP_SBC_1	465:469	VISSS	SPOP	0.5653	More...
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	12:16	VISSS	SPOP	0.6073	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_SPOP_SBC_1	446:450	VISSS	SPOP	0.9985	More...
Q8N128	Protein FAM177A1	DEG_SPOP_SBC_1	182:186	VISSS	SPOP	0.9894	More...
Q8TF20	Zinc finger protein 721	DEG_SPOP_SBC_1	245:249	VISSS	SPOP	0.7681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons