DegronMD

Uniprot ID: Q86XQ3

Source protein: Cation channel sperm-associated protein 3

Source gene: CATSPER3

Class: DEG_SPOP_SBC_1

Location: 12:16

E3 ligase: SPOP

DEGRON score: 0.6073

ASA_SCORE: 90.38

COIL: 0.8754

CONS_SCORE: 0.4552

DSS_SCORE: 0.5642

HELIX: 0.0878

FCONS_SCORE: 1.1488

RIG_SCORE: 0.6212

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11I	TCGA-EO-A22R	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.3056
p.R11I	DO42713	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.3056
p.R8H	TCGA-EO-A3AY	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.2222
p.R8H	DO43202	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.2222
p.S16T	DO233550	PRAD	ICGC	VISSS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	135:139	VISSS	SPOP	0.988	More...
P29590	Protein PML	DEG_SPOP_SBC_1	558:562	VISSS	SPOP	0.999	More...
Q7RTS7	Keratin, type II cytoskeletal 74	DEG_SPOP_SBC_1	465:469	VISSS	SPOP	0.5653	More...
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	12:16	VISSS	SPOP	0.6073	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_SPOP_SBC_1	446:450	VISSS	SPOP	0.9985	More...
Q8N128	Protein FAM177A1	DEG_SPOP_SBC_1	182:186	VISSS	SPOP	0.9894	More...
Q8TF20	Zinc finger protein 721	DEG_SPOP_SBC_1	245:249	VISSS	SPOP	0.7681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons