DegronMD - Q8N128(FAM177A1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E180K	TCGA-GU-AATP	BLCA	TCGA	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2778
p.E180K	DO51894	BLCA	ICGC	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2778
p.P179Q	DO47407	SKCM	ICGC	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.T193N	DO229242	THCA	ICGC	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1389
p.M178T	SIDM00247	Gastric Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2222
p.M178T	MKN45	stomach	COSMIC	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2222
p.Q185P	ACH-000458	Skin Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7035
p.E175K	ACH-000554	Breast Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1389
p.E195Q	EFM-19	breast	COSMIC	VISSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.0833

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons