DegronMD

Uniprot ID: Q8N128

Source protein: Protein FAM177A1

Source gene: FAM177A1

Class: DEG_SPOP_SBC_1

Location: 182:186

E3 ligase: SPOP

DEGRON score: 0.9894

ASA_SCORE: 73.84

COIL: 0.8048

CONS_SCORE: 0.2793

DSS_SCORE: 0.433

HELIX: 0.0448

FCONS_SCORE: 0.8178

RIG_SCORE: 0.777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E180K	TCGA-GU-AATP	BLCA	TCGA	VISSS	DEG_SPOP_SBC_1	0.2778
p.E180K	DO51894	BLCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.2778
p.P179Q	DO47407	SKCM	ICGC	VISSS	DEG_SPOP_SBC_1	0.25
p.T193N	DO229242	THCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.1389
p.M178T	SIDM00247	Gastric Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.2222
p.M178T	MKN45	stomach	COSMIC	VISSS	DEG_SPOP_SBC_1	0.2222
p.Q185P	ACH-000458	Skin Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	0.7035
p.E175K	ACH-000554	Breast Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	0.1389
p.E195Q	EFM-19	breast	COSMIC	VISSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	135:139	VISSS	SPOP	0.988	More...
P29590	Protein PML	DEG_SPOP_SBC_1	558:562	VISSS	SPOP	0.999	More...
Q7RTS7	Keratin, type II cytoskeletal 74	DEG_SPOP_SBC_1	465:469	VISSS	SPOP	0.5653	More...
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	12:16	VISSS	SPOP	0.6073	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_SPOP_SBC_1	446:450	VISSS	SPOP	0.9985	More...
Q8N128	Protein FAM177A1	DEG_SPOP_SBC_1	182:186	VISSS	SPOP	0.9894	More...
Q8TF20	Zinc finger protein 721	DEG_SPOP_SBC_1	245:249	VISSS	SPOP	0.7681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons