DegronMD

Uniprot ID: O95625

Source protein: Zinc finger and BTB domain-containing protein 11

Source gene: ZBTB11

Class: DEG_SPOP_SBC_1

Location: 446:450

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 68.98

COIL: 0.712

CONS_SCORE: 0.4238

DSS_SCORE: 0.6483

HELIX: 0.0892

FCONS_SCORE: 1.0659

RIG_SCORE: 0.6376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D459V	TCGA-CG-4455	STAD	TCGA	VISSS	DEG_SPOP_SBC_1	0.0833
p.D459V	DO38719	STAD	ICGC	VISSS	DEG_SPOP_SBC_1	0.0833
p.S448I	TCGA-EY-A1GI	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.8453
p.S448I	DO41211	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.8453
p.S450L	DO232761	PBCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.8778
p.S448R	ACH-001310	Non-Cancerous	CCLE	VISSS	DEG_SPOP_SBC_1	0.8538
p.K440E	ACH-002061	Leukemia	CCLE	VISSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	135:139	VISSS	SPOP	0.988	More...
P29590	Protein PML	DEG_SPOP_SBC_1	558:562	VISSS	SPOP	0.999	More...
Q7RTS7	Keratin, type II cytoskeletal 74	DEG_SPOP_SBC_1	465:469	VISSS	SPOP	0.5653	More...
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	12:16	VISSS	SPOP	0.6073	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_SPOP_SBC_1	446:450	VISSS	SPOP	0.9985	More...
Q8N128	Protein FAM177A1	DEG_SPOP_SBC_1	182:186	VISSS	SPOP	0.9894	More...
Q8TF20	Zinc finger protein 721	DEG_SPOP_SBC_1	245:249	VISSS	SPOP	0.7681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons