DegronMD

Uniprot ID: P29590

Source protein: Protein PML

Source gene: PML

Class: DEG_SPOP_SBC_1

Location: 558:562

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 63.36

COIL: 0.7454

CONS_SCORE: 0.5809

DSS_SCORE: 0.6363

HELIX: 0.0502

FCONS_SCORE: 1.1986

RIG_SCORE: 0.7108

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V556I	TCGA-B5-A0JX	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.2778
p.V556I	DO43322	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.2778
p.E568K	TCGA-D1-A103	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	0.1667
p.E568K	TCGA-EA-A97N	CESC	TCGA	VISSS	DEG_SPOP_SBC_1	0.1667
p.E568K	DO49935	CESC	ICGC	VISSS	DEG_SPOP_SBC_1	0.1667
p.E568K	DO42312	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.1667
p.G550W	TCGA-FY-A3BL	THCA	TCGA	VISSS	DEG_SPOP_SBC_1	0.1111
p.G550W	DO40190	THCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.1111
p.S561N	TCGA-VQ-A924	STAD	TCGA	VISSS	DEG_SPOP_SBC_1	0.818
p.S561N	DO51795	STAD	ICGC	VISSS	DEG_SPOP_SBC_1	0.818
p.A558V	DO7780	COAD	ICGC	VISSS	DEG_SPOP_SBC_1	0.6936
p.A558V	DO233088	GACA	ICGC	VISSS	DEG_SPOP_SBC_1	0.6936
p.A558V	DO43186	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.6936
p.A549V	DO230312	COCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.0833
p.G550R	DO233115	GACA	ICGC	VISSS	DEG_SPOP_SBC_1	0.1111
p.R555C	DO233731	GACA	ICGC	VISSS	DEG_SPOP_SBC_1	0.25
p.R555C	DO219774	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	0.25
p.P564Q	DO228969	LICA	ICGC	VISSS	DEG_SPOP_SBC_1	0.2778
p.V556F	DO229025	LICA	ICGC	VISSS	DEG_SPOP_SBC_1	0.2778
p.G549W	DO23108	LINC	ICGC	VISSS	DEG_SPOP_SBC_1	0.0833
p.G549W	DO45041	LINC	ICGC	VISSS	DEG_SPOP_SBC_1	0.0833
p.S571F	DO220902	MELA	ICGC	VISSS	DEG_SPOP_SBC_1	0.0833
p.R555H	DO36386	READ	ICGC	VISSS	DEG_SPOP_SBC_1	0.25
p.P564S	DO218863	SKCA	ICGC	VISSS	DEG_SPOP_SBC_1	0.2778
p.A567V	SIDM01314	Colorectal Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.1944
p.A549T	SIDM01265	Plasma Cell Myeloma	GDSC	VISSS	DEG_SPOP_SBC_1	0.0833
p.A549T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.0833
p.M572V	SIDM01183	Other Solid Cancers	GDSC	VISSS	DEG_SPOP_SBC_1	0.0556
p.M572V	UMC-11	lung	COSMIC	VISSS	DEG_SPOP_SBC_1	0.0556
p.V558L	SIDM00537	Colorectal Carcinoma	GDSC	VISSS	DEG_SPOP_SBC_1	0.6765
p.V558L	ACH-001345	Colon/Colorectal Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	0.6765
p.V558L	GP5d	large_intestine	COSMIC	VISSS	DEG_SPOP_SBC_1	0.6765
p.N569Y	ACH-001385	Head and Neck Cancer	CCLE	VISSS	DEG_SPOP_SBC_1	0.1389
p.S563N	MZ7-mel	skin	COSMIC	VISSS	DEG_SPOP_SBC_1	0.3056
p.W560C	GP5d	large_intestine	COSMIC	VISSS	DEG_SPOP_SBC_1	0.7

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	135:139	VISSS	SPOP	0.988	More...
P29590	Protein PML	DEG_SPOP_SBC_1	558:562	VISSS	SPOP	0.999	More...
Q7RTS7	Keratin, type II cytoskeletal 74	DEG_SPOP_SBC_1	465:469	VISSS	SPOP	0.5653	More...
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	12:16	VISSS	SPOP	0.6073	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_SPOP_SBC_1	446:450	VISSS	SPOP	0.9985	More...
Q8N128	Protein FAM177A1	DEG_SPOP_SBC_1	182:186	VISSS	SPOP	0.9894	More...
Q8TF20	Zinc finger protein 721	DEG_SPOP_SBC_1	245:249	VISSS	SPOP	0.7681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VISSS

Degron related mutations and impact score

Drug responses associated with PML mutations

All proteins holding degron of VISSS