DegronMD - O95625(ZBTB11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G140R	TCGA-94-8490	LUSC	TCGA	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation rewiring degron network	0.2778
p.G140R	DO52021	LUSC	ICGC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation rewiring degron network	0.2778
p.S435Y	TCGA-AX-A0J0	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1389
p.S435Y	TCGA-E6-A1LX	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1389
p.S435Y	DO41020	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1389
p.S435Y	DO41133	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	442:446	Mutation rewiring degron network	0.1389
p.D459V	TCGA-CG-4455	STAD	TCGA	VISSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.D459V	DO38719	STAD	ICGC	VISSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.S448I	TCGA-EY-A1GI	UCEC	TCGA	VISSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.8453
p.S448I	DO41211	UCEC	ICGC	VISSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.8453
p.V132F	TCGA-L5-A8NS	ESCA	TCGA	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation rewiring degron network	0.0556
p.E144K	DO48420	BLCA	ICGC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation altering degron motif	0.7022
p.E444D	DO222762	COCA	ICGC	SKENV	DEG_APCC_KENBOX_2	442:446	Mutation altering degron motif	0.6758
p.D155V	DO233259	GACA	ICGC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation rewiring degron network	0.1111
p.D142E	DO229045	LICA	ICGC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation altering degron motif	0.6758
p.S450L	DO232761	PBCA	ICGC	VISSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.8778
p.S133L	SIDM00630	Breast Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation rewiring degron network	0.0833
p.S133L	ACH-000876	Breast Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation rewiring degron network	0.0833
p.E4G	SIDM00779	Colorectal Carcinoma	GDSC	YRAILRYLT	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.E4G	ACH-000491	Colon/Colorectal Cancer	CCLE	YRAILRYLT	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.D155N	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation rewiring degron network	0.1111
p.L143I	SIDM00839	Colorectal Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation altering degron motif	0.6063
p.L143I	ACH-000950	Colon/Colorectal Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation altering degron motif	0.6063
p.L143I	LoVo	large intestine	COSMIC	DLESGE	DEG_Kelch_Keap1_1	142:147	Mutation altering degron motif	0.6063
p.S448R	ACH-001310	Non-Cancerous	CCLE	VISSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.8538
p.K440E	ACH-002061	Leukemia	CCLE	VISSS	DEG_SPOP_SBC_1	446:450	Mutation substituting flanking lysine	0.2778

Kaplan plot for ZBTB11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB11

UniProt ID: O95625

Entrez ID: 27107

Protein name: Zinc finger and BTB domain-containing protein 11

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB11 in