DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
YRAILRYLT
Uniprot ID:
O95625
Source protein:
Zinc finger and BTB domain-containing protein 11
Source gene:
ZBTB11
Class:
DEG_APCC_DBOX_1
Location:
7:15
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5017
ASA_SCORE:
47.4444
COIL:
0.0753
CONS_SCORE:
0.9127
DSS_SCORE:
0.4409
HELIX:
0.9203
FCONS_SCORE:
0.9732
RIG_SCORE:
0.8211
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E4G
SIDM00779
Colorectal Carcinoma
GDSC
YRAILRYLT
DEG_APCC_DBOX_1
0.25
p.E4G
ACH-000491
Colon/Colorectal Cancer
CCLE
YRAILRYLT
DEG_APCC_DBOX_1
0.25
Drug responses associated with ZBTB11 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of YRAILRYLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95625
Zinc finger and BTB domain-containing protein 11
DEG_APCC_DBOX_1
7:15
YRAILRYLT
APC,CDC20,FZR1
0.5017
More...