DegronMD

Uniprot ID: O95625

Source protein: Zinc finger and BTB domain-containing protein 11

Source gene: ZBTB11

Class: DEG_Kelch_Keap1_1

Location: 142:147

E3 ligase: KEAP1

DEGRON score: 0.506

ASA_SCORE: 103.0333

COIL: 0.9015

CONS_SCORE: 0.585

DSS_SCORE: 0.6743

HELIX: 0.0658

FCONS_SCORE: 0.9155

RIG_SCORE: 0.6452

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G140R	TCGA-94-8490	LUSC	TCGA	DLESGE	DEG_Kelch_Keap1_1	0.2778
p.G140R	DO52021	LUSC	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.2778
p.V132F	TCGA-L5-A8NS	ESCA	TCGA	DLESGE	DEG_Kelch_Keap1_1	0.0556
p.E144K	DO48420	BLCA	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.7022
p.D155V	DO233259	GACA	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.1111
p.D142E	DO229045	LICA	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.6758
p.S133L	SIDM00630	Breast Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	0.0833
p.S133L	ACH-000876	Breast Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	0.0833
p.D155N	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	0.1111
p.L143I	SIDM00839	Colorectal Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	0.6063
p.L143I	ACH-000950	Colon/Colorectal Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	0.6063
p.L143I	LoVo	large_intestine	COSMIC	DLESGE	DEG_Kelch_Keap1_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CB8	Rho GTPase-activating protein 19	DEG_Kelch_Keap1_1	165:170	DLESGE	KEAP1	0.8605	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_Kelch_Keap1_1	142:147	DLESGE	KEAP1	0.506	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons