DegronMD - Q14CB8(ARHGAP19)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K416M	TCGA-77-8140	LUSC	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation blocking ubiquitination signal	0.5556
p.K416M	DO26834	LUSC	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation blocking ubiquitination signal	0.5556
p.H172Y	TCGA-85-8479	LUSC	TCGA	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.2778
p.N174H	TCGA-AX-A0J0	UCEC	TCGA	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.2222
p.E461K	TCGA-AZ-4315	COAD	TCGA	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation altering degron motif	0.7022
p.E461K	DO8842	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation altering degron motif	0.7022
p.R463M	TCGA-D3-A2JB	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation altering degron motif	0.7521
p.R463M	DO47607	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation altering degron motif	0.7521
p.G169W	TCGA-D3-A2JB	SKCM	TCGA	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation altering degron motif	0.7825
p.S412F	TCGA-ER-A19N	SKCM	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.2222
p.S412F	DO37452	SKCM	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.2222
p.S400L	TCGA-FW-A3R5	SKCM	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.3056
p.S400L	DO37406	SKCM	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.3056
p.L392F	TCGA-QK-A6IG	HNSC	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.0833
p.L392F	DO50002	HNSC	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.0833
p.L166V	TCGA-XE-AAOB	TGCT	TCGA	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation altering degron motif	0.5654
p.E461Q	TCGA-XF-A8HD	BLCA	TCGA	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation altering degron motif	0.6744
p.E461Q	DO49795	BLCA	ICGC	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation altering degron motif	0.6744
p.S468C	TCGA-XF-AAN0	BLCA	TCGA	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation rewiring degron network	0.1944
p.S468C	DO51941	BLCA	ICGC	SKENR	DEG_APCC_KENBOX_2	459:463	Mutation rewiring degron network	0.1944
p.E180K	DO558	BLCA	ICGC	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.0556
p.P405T	DO229041	LICA	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation altering degron motif	0.7031
p.H163Y	DO45443	LUSC	ICGC	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.2778
p.G160W	DO47607	SKCM	ICGC	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.1944
p.N165H	DO41133	UCEC	ICGC	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation altering degron motif	0.7423
p.V176I	SIDM01617	Endometrial Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.1667
p.V176I	ACH-000994	Endometrial/Uterine Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.1667
p.E170K	ACH-000868	Lung Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation altering degron motif	0.7022
p.R392H	NCI-H64	lung	COSMIC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.0833
p.L175V	H513	pleura	COSMIC	DLESGE	DEG_Kelch_Keap1_1	165:170	Mutation rewiring degron network	0.1944
p.R410C	ES-2	ovary	COSMIC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.2778
p.R412H	NCI-H64	lung	COSMIC	LTQTPGRE	DEG_SCF_FBW7_2	401:408	Mutation rewiring degron network	0.2222

Kaplan plot for ARHGAP19 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP19

UniProt ID: Q14CB8

Entrez ID: 84986

Protein name: Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP19 in