DegronMD

Uniprot ID: Q14CB8

Source protein: Rho GTPase-activating protein 19

Source gene: ARHGAP19

Class: DEG_APCC_KENBOX_2

Location: 459:463

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.996

ASA_SCORE: 104.82

COIL: 0.5172

CONS_SCORE: 0.5522

DSS_SCORE: 0.5057

HELIX: 0.4546

FCONS_SCORE: 1.2068

RIG_SCORE: 0.7121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E461K	TCGA-AZ-4315	COAD	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7022
p.E461K	DO8842	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7022
p.R463M	TCGA-D3-A2JB	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7521
p.R463M	DO47607	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7521
p.E461Q	TCGA-XF-A8HD	BLCA	TCGA	SKENR	DEG_APCC_KENBOX_2	0.6744
p.E461Q	DO49795	BLCA	ICGC	SKENR	DEG_APCC_KENBOX_2	0.6744
p.S468C	TCGA-XF-AAN0	BLCA	TCGA	SKENR	DEG_APCC_KENBOX_2	0.1944
p.S468C	DO51941	BLCA	ICGC	SKENR	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CB8	Rho GTPase-activating protein 19	DEG_APCC_KENBOX_2	459:463	SKENR	APC,CDC20,FZR1	0.996	More...
Q4G0J3	La-related protein 7	DEG_APCC_KENBOX_2	328:332	SKENR	APC,CDC20,FZR1	0.9758	More...
Q86X24	HORMA domain-containing protein 1	DEG_APCC_KENBOX_2	354:358	SKENR	APC,CDC20,FZR1	0.9971	More...
Q9HCZ1	Zinc finger protein 334	DEG_APCC_KENBOX_2	155:159	SKENR	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons