DegronMD

Uniprot ID: Q9HCZ1

Source protein: Zinc finger protein 334

Source gene: ZNF334

Class: DEG_APCC_KENBOX_2

Location: 155:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 83.08

COIL: 0.7786

CONS_SCORE: 0.6411

DSS_SCORE: 0.487

HELIX: 0.0408

FCONS_SCORE: 1.345

RIG_SCORE: 0.7142

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G169W	TCGA-A5-A0R9	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.0556
p.K153N	TCGA-DF-A2KV	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.2778
p.R159K	TCGA-DR-A0ZM	CESC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.6126
p.F168L	TCGA-LL-A73Z	BRCA	TCGA	SKENR	DEG_APCC_KENBOX_2	0.0833
p.P162S	TCGA-ZJ-A8QR	CESC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.25
p.R153I	DO8264	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	0.2778
p.R153I	DO41903	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	0.2778
p.P156T	DO9674	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7031
p.R153S	DO22237	LGG	ICGC	SKENR	DEG_APCC_KENBOX_2	0.2778
p.P151T	DO229037	LICA	ICGC	SKENR	DEG_APCC_KENBOX_2	0.2222
p.G162E	DO37762	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	0.25
p.N164S	SIDM00608	Plasma Cell Myeloma	GDSC	SKENR	DEG_APCC_KENBOX_2	0.1944
p.N164S	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.1944
p.G146S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	0.0833
p.G146S	NCI-H23	lung	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.0833
p.G146D	SIDM00217	Colorectal Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	0.0833
p.G146D	SNU-1040	large_intestine	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.0833
p.V149L	ACH-000929	Lung Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	0.1667
p.V149L	NCI-H2110	lung	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.1667
p.V149A	ACH-000937	Leukemia	CCLE	SKENR	DEG_APCC_KENBOX_2	0.1667
p.K156N	ACH-000991	Colon/Colorectal Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	0.6918
p.K156N	SNU-81	large_intestine	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.6918
p.P162L	ACH-001518	Endometrial/Uterine Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	0.25
p.P162L	ACH-002305	Head and Neck Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	0.25
p.P162L	SKN-3	upper_aerodigestive_tract	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.25
p.P162A	LNZTA3WT4	central_nervous_system	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.25
p.P161L	SKN-3	upper_aerodigestive_tract	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.2778
p.V148L	NCI-H2110	lung	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.1389
p.M148V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.1389
p.K155N	SNU-81	large_intestine	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.6918
p.P161A	LNZTA3WT4	central_nervous_system	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CB8	Rho GTPase-activating protein 19	DEG_APCC_KENBOX_2	459:463	SKENR	APC,CDC20,FZR1	0.996	More...
Q4G0J3	La-related protein 7	DEG_APCC_KENBOX_2	328:332	SKENR	APC,CDC20,FZR1	0.9758	More...
Q86X24	HORMA domain-containing protein 1	DEG_APCC_KENBOX_2	354:358	SKENR	APC,CDC20,FZR1	0.9971	More...
Q9HCZ1	Zinc finger protein 334	DEG_APCC_KENBOX_2	155:159	SKENR	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENR

Degron related mutations and impact score

Drug responses associated with ZNF334 mutations

All proteins holding degron of SKENR