DegronMD

Uniprot ID: Q86X24

Source protein: HORMA domain-containing protein 1

Source gene: HORMAD1

Class: DEG_APCC_KENBOX_2

Location: 354:358

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9971

ASA_SCORE: 116.04

COIL: 0.7512

CONS_SCORE: 0.4202

DSS_SCORE: 0.8095

HELIX: 0.2512

FCONS_SCORE: 1.1088

RIG_SCORE: 0.6227

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R358W	TCGA-3B-A9HT	SARC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	TCGA-AA-A00N	COAD	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	TCGA-B5-A1MR	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	TCGA-E6-A1LX	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	TCGA-FR-A8YC	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	DO9876	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	DO219934	SARC	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	DO50301	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	DO41020	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358W	DO41758	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	0.7523
p.R358Q	TCGA-AP-A1DR	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.6218
p.R358Q	DO43747	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	0.6218
p.R358Q	SIDM01587	Bladder Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	0.6218
p.G347E	TCGA-D3-A8GL	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	0.1389
p.G347E	TCGA-GN-A266	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	0.1389
p.G347E	DO37432	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	0.1389
p.G347E	DO50287	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	0.1389
p.Q362K	TCGA-E6-A1LX	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.2222
p.Q362K	DO41020	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	0.2222
p.G366E	TCGA-FW-A3R5	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	0.1111
p.G366E	DO37406	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	0.1111
p.S353Y	TCGA-ND-A4WC	UCS	TCGA	SKENR	DEG_APCC_KENBOX_2	0.3056
p.G347A	DO228268	BRCA	ICGC	SKENR	DEG_APCC_KENBOX_2	0.1389
p.S354Y	DO228974	LICA	ICGC	SKENR	DEG_APCC_KENBOX_2	0.6009
p.R360T	SIDM00281	Other Solid Cancers	GDSC	SKENR	DEG_APCC_KENBOX_2	0.2778
p.R360T	ACH-002100	Skin Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	0.2778
p.R360T	DJM-1	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.2778
p.G347R	SIDM00140	Melanoma	GDSC	SKENR	DEG_APCC_KENBOX_2	0.1389
p.G347R	ACH-000968	Skin Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	0.1389
p.G347R	COLO-792	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.1389
p.R353T	DJM-1	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CB8	Rho GTPase-activating protein 19	DEG_APCC_KENBOX_2	459:463	SKENR	APC,CDC20,FZR1	0.996	More...
Q4G0J3	La-related protein 7	DEG_APCC_KENBOX_2	328:332	SKENR	APC,CDC20,FZR1	0.9758	More...
Q86X24	HORMA domain-containing protein 1	DEG_APCC_KENBOX_2	354:358	SKENR	APC,CDC20,FZR1	0.9971	More...
Q9HCZ1	Zinc finger protein 334	DEG_APCC_KENBOX_2	155:159	SKENR	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENR

Degron related mutations and impact score

Drug responses associated with HORMAD1 mutations

All proteins holding degron of SKENR