DegronMD - Q9HCZ1(ZNF334)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G169W	TCGA-A5-A0R9	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.0556
p.K153N	TCGA-DF-A2KV	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.2778
p.R159K	TCGA-DR-A0ZM	CESC	TCGA	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6126
p.F168L	TCGA-LL-A73Z	BRCA	TCGA	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.0833
p.P162S	TCGA-ZJ-A8QR	CESC	TCGA	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.25
p.R153I	DO8264	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.2778
p.R153I	DO41903	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.2778
p.P156T	DO9674	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.7031
p.R153S	DO22237	LGG	ICGC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.2778
p.P151T	DO229037	LICA	ICGC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.2222
p.G162E	DO37762	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.25
p.N164S	SIDM00608	Plasma Cell Myeloma	GDSC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1944
p.N164S	KMS-11	haematopoietic and lymphoid tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1944
p.G146S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.0833
p.G146S	NCI-H23	lung	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.0833
p.G146D	SIDM00217	Colorectal Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.0833
p.G146D	SNU-1040	large intestine	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.0833
p.V149L	ACH-000929	Lung Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1667
p.V149L	NCI-H2110	lung	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1667
p.V149A	ACH-000937	Leukemia	CCLE	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1667
p.K156N	ACH-000991	Colon/Colorectal Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6918
p.K156N	SNU-81	large intestine	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6918
p.P162L	ACH-001518	Endometrial/Uterine Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.25
p.P162L	ACH-002305	Head and Neck Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.25
p.P162L	SKN-3	upper aerodigestive tract	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.25
p.P162A	LNZTA3WT4	central nervous system	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.25
p.P161L	SKN-3	upper aerodigestive tract	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.2778
p.V148L	NCI-H2110	lung	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1389
p.M148V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1389
p.K155N	SNU-81	large intestine	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6918
p.P161A	LNZTA3WT4	central nervous system	COSMIC	SKENR	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF334

UniProt ID: Q9HCZ1

Entrez ID: 55713

Protein name: Zinc finger protein 334

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF334 in