DegronMD - Q4G0J3(LARP7)

LARP7

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A331S	TCGA-78-8660	LUAD	TCGA	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation altering degron motif	0.7588
p.E342K	TCGA-C5-A2LV	CESC	TCGA	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation substituting flanking lysine	0.1667
p.E335K	DO48987	CESC	ICGC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.25
p.A324S	DO45321	LUAD	ICGC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.2222
p.Q324L	SIDM00007	Other Solid Cancers	GDSC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.2222
p.Q324L	MCC13	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.2222
p.E333D	SIDM00009	Acute Myeloid Leukemia	GDSC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.3056
p.E333D	MC-1010	haematopoietic and lymphoid tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.3056
p.Q324H	SIDM00054	Pancreatic Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.2222
p.Q324H	PL18	pancreas	COSMIC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.2222
p.E326D	MC-1010	haematopoietic and lymphoid tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	328:332	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc