DegronMD

Uniprot ID: Q4G0J3

Source protein: La-related protein 7

Source gene: LARP7

Class: DEG_APCC_KENBOX_2

Location: 328:332

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9758

ASA_SCORE: 110.18

COIL: 0.5912

CONS_SCORE: 0.3077

DSS_SCORE: 0.4835

HELIX: 0.3818

FCONS_SCORE: 0.9901

RIG_SCORE: 0.6801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A331S	TCGA-78-8660	LUAD	TCGA	SKENR	DEG_APCC_KENBOX_2	0.7588
p.E342K	TCGA-C5-A2LV	CESC	TCGA	SKENR	DEG_APCC_KENBOX_2	0.1667
p.E335K	DO48987	CESC	ICGC	SKENR	DEG_APCC_KENBOX_2	0.25
p.A324S	DO45321	LUAD	ICGC	SKENR	DEG_APCC_KENBOX_2	0.2222
p.Q324L	SIDM00007	Other Solid Cancers	GDSC	SKENR	DEG_APCC_KENBOX_2	0.2222
p.Q324L	MCC13	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.2222
p.E333D	SIDM00009	Acute Myeloid Leukemia	GDSC	SKENR	DEG_APCC_KENBOX_2	0.3056
p.E333D	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.3056
p.Q324H	SIDM00054	Pancreatic Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	0.2222
p.Q324H	PL18	pancreas	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.2222
p.E326D	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	SKENR	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CB8	Rho GTPase-activating protein 19	DEG_APCC_KENBOX_2	459:463	SKENR	APC,CDC20,FZR1	0.996	More...
Q4G0J3	La-related protein 7	DEG_APCC_KENBOX_2	328:332	SKENR	APC,CDC20,FZR1	0.9758	More...
Q86X24	HORMA domain-containing protein 1	DEG_APCC_KENBOX_2	354:358	SKENR	APC,CDC20,FZR1	0.9971	More...
Q9HCZ1	Zinc finger protein 334	DEG_APCC_KENBOX_2	155:159	SKENR	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons