DegronMD - Q86X24(HORMAD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R358W	TCGA-3B-A9HT	SARC	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	TCGA-AA-A00N	COAD	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	TCGA-B5-A1MR	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	TCGA-E6-A1LX	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	TCGA-FR-A8YC	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	DO9876	COAD	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	DO219934	SARC	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	DO50301	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	DO41020	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358W	DO41758	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.7523
p.R358Q	TCGA-AP-A1DR	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.6218
p.R358Q	DO43747	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.6218
p.R358Q	SIDM01587	Bladder Carcinoma	GDSC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.6218
p.G347E	TCGA-D3-A8GL	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.G347E	TCGA-GN-A266	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.G347E	DO37432	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.G347E	DO50287	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.Q362K	TCGA-E6-A1LX	UCEC	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.2222
p.Q362K	DO41020	UCEC	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.2222
p.G366E	TCGA-FW-A3R5	SKCM	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1111
p.G366E	DO37406	SKCM	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1111
p.S353Y	TCGA-ND-A4WC	UCS	TCGA	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.3056
p.G347A	DO228268	BRCA	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.S354Y	DO228974	LICA	ICGC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation altering degron motif	0.6009
p.R360T	SIDM00281	Other Solid Cancers	GDSC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.2778
p.R360T	ACH-002100	Skin Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.2778
p.R360T	DJM-1	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.2778
p.G347R	SIDM00140	Melanoma	GDSC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.G347R	ACH-000968	Skin Cancer	CCLE	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.G347R	COLO-792	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.1389
p.R353T	DJM-1	skin	COSMIC	SKENR	DEG_APCC_KENBOX_2	354:358	Mutation rewiring degron network	0.3056

Kaplan plot for HORMAD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HORMAD1

UniProt ID: Q86X24

Entrez ID: 84072

Protein name: HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HORMAD1 in