DegronMD

Uniprot ID: Q14CB8

Source protein: Rho GTPase-activating protein 19

Source gene: ARHGAP19

Class: DEG_SCF_FBW7_2

Location: 401:408

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 100.7

COIL: 0.9443

CONS_SCORE: 0.5845

DSS_SCORE: 0.7003

HELIX: 0.0348

FCONS_SCORE: 1.0446

RIG_SCORE: 0.6231

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K416M	TCGA-77-8140	LUSC	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	0.5556
p.K416M	DO26834	LUSC	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	0.5556
p.S412F	TCGA-ER-A19N	SKCM	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	0.2222
p.S412F	DO37452	SKCM	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	0.2222
p.S400L	TCGA-FW-A3R5	SKCM	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	0.3056
p.S400L	DO37406	SKCM	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	0.3056
p.L392F	TCGA-QK-A6IG	HNSC	TCGA	LTQTPGRE	DEG_SCF_FBW7_2	0.0833
p.L392F	DO50002	HNSC	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	0.0833
p.P405T	DO229041	LICA	ICGC	LTQTPGRE	DEG_SCF_FBW7_2	0.7031
p.R392H	NCI-H64	lung	COSMIC	LTQTPGRE	DEG_SCF_FBW7_2	0.0833
p.R410C	ES-2	ovary	COSMIC	LTQTPGRE	DEG_SCF_FBW7_2	0.2778
p.R412H	NCI-H64	lung	COSMIC	LTQTPGRE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CB8	Rho GTPase-activating protein 19	DEG_SCF_FBW7_2	401:408	LTQTPGRE	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons