DegronMD

Uniprot ID: Q14CB8

Source protein: Rho GTPase-activating protein 19

Source gene: ARHGAP19

Class: DEG_Kelch_Keap1_1

Location: 165:170

E3 ligase: KEAP1

DEGRON score: 0.8605

ASA_SCORE: 76.9333

COIL: 0.8927

CONS_SCORE: 0.5948

DSS_SCORE: 0.3586

HELIX: 0.0765

FCONS_SCORE: 0.9558

RIG_SCORE: 0.7293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H172Y	TCGA-85-8479	LUSC	TCGA	DLESGE	DEG_Kelch_Keap1_1	0.2778
p.N174H	TCGA-AX-A0J0	UCEC	TCGA	DLESGE	DEG_Kelch_Keap1_1	0.2222
p.G169W	TCGA-D3-A2JB	SKCM	TCGA	DLESGE	DEG_Kelch_Keap1_1	0.7825
p.L166V	TCGA-XE-AAOB	TGCT	TCGA	DLESGE	DEG_Kelch_Keap1_1	0.5654
p.E180K	DO558	BLCA	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.0556
p.H163Y	DO45443	LUSC	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.2778
p.G160W	DO47607	SKCM	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.1944
p.N165H	DO41133	UCEC	ICGC	DLESGE	DEG_Kelch_Keap1_1	0.7423
p.V176I	SIDM01617	Endometrial Carcinoma	GDSC	DLESGE	DEG_Kelch_Keap1_1	0.1667
p.V176I	ACH-000994	Endometrial/Uterine Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	0.1667
p.E170K	ACH-000868	Lung Cancer	CCLE	DLESGE	DEG_Kelch_Keap1_1	0.7022
p.L175V	H513	pleura	COSMIC	DLESGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CB8	Rho GTPase-activating protein 19	DEG_Kelch_Keap1_1	165:170	DLESGE	KEAP1	0.8605	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_Kelch_Keap1_1	142:147	DLESGE	KEAP1	0.506	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons