DegronMD

Uniprot ID: P28702

Source protein: Retinoic acid receptor RXR-beta

Source gene: RXRB

Class: DEG_SCF_TRCP1_1

Location: 75:80

E3 ligase: BTRC

DEGRON score: 0.972

ASA_SCORE: 74.55

COIL: 0.8772

CONS_SCORE: 0.6495

DSS_SCORE: 0.9182

HELIX: 0.0537

FCONS_SCORE: 1.0461

RIG_SCORE: 0.4711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R81Q	TCGA-AA-3984	COAD	TCGA	DSGRDS	DEG_SCF_TRCP1_1	0.3056
p.R81Q	DO9002	COAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	0.3056
p.D75N	TCGA-F7-A624	HNSC	TCGA	DSGRDS	DEG_SCF_TRCP1_1	0.6932
p.D75N	DO44440	HNSC	ICGC	DSGRDS	DEG_SCF_TRCP1_1	0.6932
p.I66F	DO9860	COAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	0.0833
p.G89R	DO234455	ESAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	0.0833
p.G78D	DO228138	PBCA	ICGC	DSGRDS	DEG_SCF_TRCP1_1	0.7198
p.G78A	DO222342	STAD	ICGC	DSGRDS	DEG_SCF_TRCP1_1	0.754
p.G78A	DO42977	UCEC	ICGC	DSGRDS	DEG_SCF_TRCP1_1	0.754
p.P90S	ACH-000987	Skin Cancer	CCLE	DSGRDS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28702	Retinoic acid receptor RXR-beta	DEG_SCF_TRCP1_1	75:80	DSGRDS	BTRC	0.972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons