DegronMD - Q9BRK4(LZTS2)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S191C	TCGA-04-1331	OV	TCGA	PASSS	DEG_SPOP_SBC_1	186:190	Mutation blocking phosphorylation signal	0.75
p.S191C	DO28119	OV	ICGC	PASSS	DEG_SPOP_SBC_1	186:190	Mutation blocking phosphorylation signal	0.75
p.S301A	TCGA-24-2280	OV	TCGA	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation blocking phosphorylation signal	0.75
p.S301A	DO28511	OV	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation blocking phosphorylation signal	0.75
p.S301C	TCGA-24-2280	OV	TCGA	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation blocking phosphorylation signal	0.75
p.S301C	DO28511	OV	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation blocking phosphorylation signal	0.75
p.P315S	TCGA-2W-A8YY	CESC	TCGA	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.0833
p.P315S	DO223732	CESC	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.0833
p.P186H	TCGA-A5-A1OF	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.7694
p.P186H	DO42568	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.7694
p.P243S	TCGA-A7-A0CE	BRCA	TCGA	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.P243S	DO4080	BRCA	ICGC	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.3056
p.S214A	TCGA-AJ-A3EK	UCEC	TCGA	GRNSLSSLP	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1389
p.S214A	TCGA-AJ-A3EK	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.1944
p.S214A	DO41584	UCEC	ICGC	GRNSLSSLP	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1389
p.S214A	DO41584	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.1944
p.R262Q	TCGA-AP-A0LJ	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.0556
p.R262Q	TCGA-DK-AA6U	BLCA	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.0556
p.R262Q	DO219008	BLCA	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.0556
p.R262Q	DO42145	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.0556
p.L285I	TCGA-AP-A1DK	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1389
p.L285I	DO42033	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1389
p.D219N	TCGA-BS-A0UF	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation altering degron motif	0.6932
p.D219N	DO41488	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation altering degron motif	0.6932
p.S301F	TCGA-D3-A8GR	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation blocking phosphorylation signal	0.75
p.S301F	DO51247	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation blocking phosphorylation signal	0.75
p.R275W	TCGA-DF-A2KU	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation altering degron motif	0.7523
p.R275W	DO218693	GACA	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation altering degron motif	0.7523
p.R275W	DO223286	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation altering degron motif	0.7523
p.P268S	TCGA-DI-A1BU	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.2222
p.P268S	DO42023	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.2222
p.S220Y	TCGA-DU-6392	LGG	TCGA	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation altering degron motif	0.8231
p.S220Y	DO22237	LGG	ICGC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation altering degron motif	0.8231
p.P186L	TCGA-E9-A22B	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.7582
p.P186L	DO1454	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.7582
p.S306F	TCGA-EE-A29E	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7982
p.S306F	DO37831	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7982
p.H270N	TCGA-EE-A2M7	SKCM	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.2778
p.H270N	DO37847	SKCM	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.2778
p.S193F	TCGA-EE-A2MR	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	186:190	Mutation blocking phosphorylation signal	0.6944
p.S193F	DO37819	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	186:190	Mutation blocking phosphorylation signal	0.6944
p.S242F	TCGA-EE-A2MR	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.7982
p.S242F	DO37819	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.7982
p.P265L	TCGA-EY-A215	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1389
p.P265L	DO42665	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1389
p.S279N	TCGA-IB-7651	PAAD	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.3056
p.S279N	DO46657	PAAD	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.3056
p.P312S	TCGA-VQ-A91K	STAD	TCGA	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1667
p.P312S	DO51785	STAD	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1667
p.G234R	DO50383	ESAD	ICGC	GRNSLSSLP	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1944
p.G234R	DO50383	ESAD	ICGC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.0556
p.G234R	DO50383	ESAD	ICGC	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2222
p.G245R	DO233634	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.25
p.G244S	DO11854	GBM	ICGC	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2778
p.G297V	DO228978	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.G297V	DO229006	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.R299W	SIDM00993	Plasma Cell Myeloma	GDSC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	ACH-000705	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	ACH-000838	Myeloma	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	ACH-001113	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	ACH-001207	Non-Cancerous	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	ACH-002156	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R299W	ACH-002263	Esophageal Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.P313L	SIDM00189	Melanoma	GDSC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1389
p.P313L	ACH-002098	Skin Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1389
p.P313L	CP67-MEL	skin	COSMIC	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1389
p.S196F	SIDM00790	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1667
p.S196F	ACH-002371	Non-Cancerous	CCLE	PASSS	DEG_SPOP_SBC_1	186:190	Mutation rewiring degron network	0.1667
p.A209V	SIDM01228	Melanoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.0556
p.A209V	CHL-1	skin	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.0556
p.G234V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	GRNSLSSLP	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1944
p.G234V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.0556
p.G234V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2222
p.G234V	ACH-000888	Lung Cancer	CCLE	GRNSLSSLP	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1944
p.G234V	ACH-000888	Lung Cancer	CCLE	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.0556
p.G234V	ACH-000888	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2222
p.G234V	NCI-H1793	lung	COSMIC	GRNSLSSLP	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1944
p.G234V	NCI-H1793	lung	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	219:224	Mutation rewiring degron network	0.0556
p.G234V	NCI-H1793	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.2222
p.T266I	SIDM01439	Hepatocellular Carcinoma	GDSC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1667
p.T266I	ACH-000537	Liver Cancer	CCLE	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1667
p.A187V	ACH-000455	Brain Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	186:190	Mutation altering degron motif	0.5825
p.L285P	ACH-000505	Sarcoma	CCLE	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1389
p.L285P	RKN	ovary	COSMIC	DSGRSSS	DEG_SCF_TRCP1_1	272:278	Mutation rewiring degron network	0.1389
p.S301P	ACH-001610	Brain Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	302:306	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LZTS2

UniProt ID: Q9BRK4

Entrez ID: 84445

Protein name: Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LZTS2 in