DegronMD

Uniprot ID: Q9BRK4

Source protein: Leucine zipper putative tumor suppressor 2

Source gene: LZTS2

Class: DEG_APCC_DBOX_1

Location: 221:229

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 69.6889

COIL: 0.8874

CONS_SCORE: 0.6518

DSS_SCORE: 0.5464

HELIX: 0.076

FCONS_SCORE: 1.1072

RIG_SCORE: 0.6279

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S214A	TCGA-AJ-A3EK	UCEC	TCGA	GRNSLSSLP	DEG_APCC_DBOX_1	0.1389
p.S214A	DO41584	UCEC	ICGC	GRNSLSSLP	DEG_APCC_DBOX_1	0.1389
p.G234R	DO50383	ESAD	ICGC	GRNSLSSLP	DEG_APCC_DBOX_1	0.1944
p.G234V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	GRNSLSSLP	DEG_APCC_DBOX_1	0.1944
p.G234V	ACH-000888	Lung Cancer	CCLE	GRNSLSSLP	DEG_APCC_DBOX_1	0.1944
p.G234V	NCI-H1793	lung	COSMIC	GRNSLSSLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_APCC_DBOX_1	221:229	GRNSLSSLP	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons