DegronMD

Uniprot ID: Q9BRK4

Source protein: Leucine zipper putative tumor suppressor 2

Source gene: LZTS2

Class: DEG_SCF_TRCP1_1

Location: 219:224

E3 ligase: BTRC

DEGRON score: 0.9995

ASA_SCORE: 76.2167

COIL: 0.857

CONS_SCORE: 0.6642

DSS_SCORE: 0.5309

HELIX: 0.1067

FCONS_SCORE: 1.0673

RIG_SCORE: 0.6163

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S214A	TCGA-AJ-A3EK	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.1944
p.S214A	DO41584	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.1944
p.D219N	TCGA-BS-A0UF	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.6932
p.D219N	DO41488	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.6932
p.S220Y	TCGA-DU-6392	LGG	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.8231
p.S220Y	DO22237	LGG	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.8231
p.G234R	DO50383	ESAD	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.0556
p.A209V	SIDM01228	Melanoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.0556
p.A209V	CHL-1	skin	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	0.0556
p.G234V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.0556
p.G234V	ACH-000888	Lung Cancer	CCLE	DSGRNS	DEG_SCF_TRCP1_1	0.0556
p.G234V	NCI-H1793	lung	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SCF_TRCP1_1	219:224	DSGRNS	BTRC	0.9995	More...
Q9Y250	Leucine zipper putative tumor suppressor 1	DEG_SCF_TRCP1_1	173:178	DSGRNS	BTRC	0.9975	More...
O60299	Leucine zipper putative tumor suppressor 3	DEG_SCF_TRCP1_1	218:223	DSGRNS	BTRC	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons