DegronMD

Uniprot ID: Q9Y250

Source protein: Leucine zipper putative tumor suppressor 1

Source gene: LZTS1

Class: DEG_SCF_TRCP1_1

Location: 173:178

E3 ligase: BTRC

DEGRON score: 0.9975

ASA_SCORE: 73.5

COIL: 0.8827

CONS_SCORE: 0.518

DSS_SCORE: 0.6158

HELIX: 0.0818

FCONS_SCORE: 1.1761

RIG_SCORE: 0.569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M179I	TCGA-60-2722	LUSC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.3056
p.M179I	DO26798	LUSC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.3056
p.S180P	TCGA-A5-A1OF	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.2778
p.S180P	DO42568	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.2778
p.S186N	TCGA-AA-3492	COAD	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.1111
p.S186N	DO8224	COAD	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.1111
p.S178F	TCGA-B5-A3FC	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.7982
p.S178F	DO41871	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.7982
p.R176L	TCGA-BF-A1PU	SKCM	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.7316
p.R176L	DO50278	SKCM	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.7316
p.S181N	TCGA-D1-A2G6	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.25
p.S181N	DO41991	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.25
p.P183S	TCGA-DF-A2KV	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.1944
p.P183S	DO227646	COCA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.1944
p.P183S	DO219771	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.1944
p.A170V	TCGA-E2-A1LH	BRCA	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.25
p.T184P	TCGA-NQ-A57I	MESO	TCGA	DSGRNS	DEG_SCF_TRCP1_1	0.1667
p.S174Y	DO228971	LICA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.712
p.D173E	DO228985	LICA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.6758
p.L166M	DO229029	LICA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.1389
p.S168P	DO231813	LINC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	0.1944
p.R176Q	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.6218
p.R176Q	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.6218
p.R176Q	SIDM00681	Colorectal Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.6218
p.R176Q	SIDM01641	Non-Cancerous	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SCF_TRCP1_1	219:224	DSGRNS	BTRC	0.9995	More...
Q9Y250	Leucine zipper putative tumor suppressor 1	DEG_SCF_TRCP1_1	173:178	DSGRNS	BTRC	0.9975	More...
O60299	Leucine zipper putative tumor suppressor 3	DEG_SCF_TRCP1_1	218:223	DSGRNS	BTRC	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons