DegronMD - Q9Y250(LZTS1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M179I	TCGA-60-2722	LUSC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.3056
p.M179I	DO26798	LUSC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.3056
p.S180P	TCGA-A5-A1OF	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.2778
p.S180P	DO42568	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.2778
p.D39G	TCGA-A8-A09A	BRCA	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.D39G	DO2955	BRCA	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.S186N	TCGA-AA-3492	COAD	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1111
p.S186N	DO8224	COAD	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1111
p.F65I	TCGA-AX-A06F	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.F65I	DO41752	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.D39N	TCGA-AX-A2HC	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.D39N	TCGA-VS-A8EH	CESC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.D39N	DO51620	CESC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.D39N	DO234193	ESAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.D39N	DO41572	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.S178F	TCGA-B5-A3FC	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.7982
p.S178F	DO41871	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.7982
p.R176L	TCGA-BF-A1PU	SKCM	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.7316
p.R176L	DO50278	SKCM	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.7316
p.E63K	TCGA-D1-A16X	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.1111
p.E63K	TCGA-DD-AADJ	LIHC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.1111
p.E63K	DO52234	LIHC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.1111
p.E63K	DO41799	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.1111
p.S181N	TCGA-D1-A2G6	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.25
p.S181N	DO41991	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.25
p.G40R	TCGA-D5-6536	COAD	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0833
p.G40R	DO8200	COAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0833
p.P183S	TCGA-DF-A2KV	UCEC	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1944
p.P183S	DO227646	COCA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1944
p.P183S	DO219771	UCEC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1944
p.A170V	TCGA-E2-A1LH	BRCA	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.25
p.F65L	TCGA-EO-A3B0	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.F65L	DO219773	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.0556
p.T184P	TCGA-NQ-A57I	MESO	TCGA	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1667
p.H52N	DO50401	ESAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.6312
p.K54T	DO50342	ESAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.6195
p.F46L	DO228948	LICA	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.25
p.S174Y	DO228971	LICA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.712
p.D173E	DO228985	LICA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.6758
p.L166M	DO229029	LICA	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1389
p.S168P	DO231813	LINC	ICGC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation rewiring degron network	0.1944
p.R176Q	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.6218
p.R176Q	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.6218
p.R176Q	SIDM00681	Colorectal Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.6218
p.R176Q	SIDM01641	Non-Cancerous	GDSC	DSGRNS	DEG_SCF_TRCP1_1	173:178	Mutation altering degron motif	0.6218
p.G53R	SIDM00418	Thyroid Gland Carcinoma	GDSC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.6457
p.G53R	ACH-000716	Thyroid Cancer	CCLE	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.6457
p.G53R	TT2609-C02	thyroid	COSMIC	DSGHGKS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.6457

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LZTS1

UniProt ID: Q9Y250

Entrez ID: 11178

Protein name: Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LZTS1 in