DegronMD

Uniprot ID: Q9Y250

Source protein: Leucine zipper putative tumor suppressor 1

Source gene: LZTS1

Class: DEG_SCF_TRCP1_1

Location: 49:55

E3 ligase: BTRC

DEGRON score: 0.9184

ASA_SCORE: 77.0143

COIL: 0.8741

CONS_SCORE: 0.4003

DSS_SCORE: 0.4666

HELIX: 0.0401

FCONS_SCORE: 0.9754

RIG_SCORE: 0.5945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D39G	TCGA-A8-A09A	BRCA	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.D39G	DO2955	BRCA	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.F65I	TCGA-AX-A06F	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.F65I	DO41752	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.D39N	TCGA-AX-A2HC	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.D39N	TCGA-VS-A8EH	CESC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.D39N	DO51620	CESC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.D39N	DO234193	ESAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.D39N	DO41572	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.E63K	TCGA-D1-A16X	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.1111
p.E63K	TCGA-DD-AADJ	LIHC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.1111
p.E63K	DO52234	LIHC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.1111
p.E63K	DO41799	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.1111
p.G40R	TCGA-D5-6536	COAD	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.0833
p.G40R	DO8200	COAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.0833
p.F65L	TCGA-EO-A3B0	UCEC	TCGA	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.F65L	DO219773	UCEC	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.0556
p.H52N	DO50401	ESAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.6312
p.K54T	DO50342	ESAD	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.6195
p.F46L	DO228948	LICA	ICGC	DSGHGKS	DEG_SCF_TRCP1_1	0.25
p.G53R	SIDM00418	Thyroid Gland Carcinoma	GDSC	DSGHGKS	DEG_SCF_TRCP1_1	0.6457
p.G53R	ACH-000716	Thyroid Cancer	CCLE	DSGHGKS	DEG_SCF_TRCP1_1	0.6457
p.G53R	TT2609-C02	thyroid	COSMIC	DSGHGKS	DEG_SCF_TRCP1_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y250	Leucine zipper putative tumor suppressor 1	DEG_SCF_TRCP1_1	49:55	DSGHGKS	BTRC	0.9184	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons