DegronMD - O60299(LZTS3)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D272Y	TCGA-60-2698	LUSC	TCGA	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1944
p.D272Y	DO26469	LUSC	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1944
p.L224I	TCGA-AP-A059	UCEC	TCGA	GRNSLTSLP	DEG_APCC_DBOX_1	220:228	Mutation altering degron motif	0.7174
p.L224I	DO41361	UCEC	ICGC	GRNSLTSLP	DEG_APCC_DBOX_1	220:228	Mutation altering degron motif	0.7174
p.S268L	TCGA-BQ-5885	KIRP	TCGA	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.0833
p.S268L	DO20921	KIRP	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.0833
p.S268L	DO220872	MELA	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.0833
p.G269C	TCGA-EI-6507	READ	TCGA	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1111
p.G269C	DO36675	READ	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1111
p.R293W	TCGA-EO-A22U	UCEC	TCGA	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.0556
p.R293W	DO43755	UCEC	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.0556
p.R280W	TCGA-FI-A2D0	UCEC	TCGA	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7523
p.R280W	DO43891	UCEC	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7523
p.R280W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7523
p.R280W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7523
p.R280W	ACH-000995	Leukemia	CCLE	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7523
p.R280W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7523
p.R293Q	DO222794	COCA	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.0556
p.A281T	DO233944	GACA	ICGC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.6028
p.T225K	DO229026	LICA	ICGC	GRNSLTSLP	DEG_APCC_DBOX_1	220:228	Mutation altering degron motif	0.6195
p.S288L	SIDM01943	Colorectal Carcinoma	GDSC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1944
p.A209V	SIDM01943	Colorectal Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation rewiring degron network	0.0833
p.A209V	SIDM00681	Colorectal Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation rewiring degron network	0.0833
p.A209V	ACH-000252	Colon/Colorectal Cancer	CCLE	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation rewiring degron network	0.0833
p.A209V	LS-1034	large intestine	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation rewiring degron network	0.0833
p.M291I	SIDM01156	Small Cell Lung Carcinoma	GDSC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1111
p.M291I	ACH-000890	Lung Cancer	CCLE	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1111
p.M291I	SW1271	lung	COSMIC	DSGRASS	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1111
p.G220R	SIDM00357	Small Cell Lung Carcinoma	GDSC	GRNSLTSLP	DEG_APCC_DBOX_1	220:228	Mutation altering degron motif	0.6457
p.G220R	SIDM00357	Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation altering degron motif	0.7568
p.G220R	ACH-002193	Lung Cancer	CCLE	GRNSLTSLP	DEG_APCC_DBOX_1	220:228	Mutation altering degron motif	0.6457
p.G220R	ACH-002193	Lung Cancer	CCLE	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation altering degron motif	0.7568
p.G220R	RERF-LC-FM	lung	COSMIC	GRNSLTSLP	DEG_APCC_DBOX_1	220:228	Mutation altering degron motif	0.6457
p.G220R	RERF-LC-FM	lung	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation altering degron motif	0.7568
p.S232P	DBTRG-05MG	central nervous system	COSMIC	GRNSLTSLP	DEG_APCC_DBOX_1	220:228	Mutation rewiring degron network	0.2222
p.S232P	DBTRG-05MG	central nervous system	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	218:223	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LZTS3

UniProt ID: O60299

Entrez ID: 9762

Protein name: Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LZTS3 in