DegronMD

Uniprot ID: O60299

Source protein: Leucine zipper putative tumor suppressor 3

Source gene: LZTS3

Class: DEG_SCF_TRCP1_1

Location: 277:283

E3 ligase: BTRC

DEGRON score: 0.9986

ASA_SCORE: 74.6857

COIL: 0.8546

CONS_SCORE: 0.4741

DSS_SCORE: 0.6486

HELIX: 0.0744

FCONS_SCORE: 1.0421

RIG_SCORE: 0.583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D272Y	TCGA-60-2698	LUSC	TCGA	DSGRASS	DEG_SCF_TRCP1_1	0.1944
p.D272Y	DO26469	LUSC	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.1944
p.S268L	TCGA-BQ-5885	KIRP	TCGA	DSGRASS	DEG_SCF_TRCP1_1	0.0833
p.S268L	DO20921	KIRP	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.0833
p.S268L	DO220872	MELA	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.0833
p.G269C	TCGA-EI-6507	READ	TCGA	DSGRASS	DEG_SCF_TRCP1_1	0.1111
p.G269C	DO36675	READ	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.1111
p.R293W	TCGA-EO-A22U	UCEC	TCGA	DSGRASS	DEG_SCF_TRCP1_1	0.0556
p.R293W	DO43755	UCEC	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.0556
p.R280W	TCGA-FI-A2D0	UCEC	TCGA	DSGRASS	DEG_SCF_TRCP1_1	0.7523
p.R280W	DO43891	UCEC	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.7523
p.R280W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGRASS	DEG_SCF_TRCP1_1	0.7523
p.R280W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGRASS	DEG_SCF_TRCP1_1	0.7523
p.R280W	ACH-000995	Leukemia	CCLE	DSGRASS	DEG_SCF_TRCP1_1	0.7523
p.R280W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRASS	DEG_SCF_TRCP1_1	0.7523
p.R293Q	DO222794	COCA	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.0556
p.A281T	DO233944	GACA	ICGC	DSGRASS	DEG_SCF_TRCP1_1	0.6028
p.S288L	SIDM01943	Colorectal Carcinoma	GDSC	DSGRASS	DEG_SCF_TRCP1_1	0.1944
p.M291I	SIDM01156	Small Cell Lung Carcinoma	GDSC	DSGRASS	DEG_SCF_TRCP1_1	0.1111
p.M291I	ACH-000890	Lung Cancer	CCLE	DSGRASS	DEG_SCF_TRCP1_1	0.1111
p.M291I	SW1271	lung	COSMIC	DSGRASS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60299	Leucine zipper putative tumor suppressor 3	DEG_SCF_TRCP1_1	277:283	DSGRASS	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons