DegronMD

Uniprot ID: O60299

Source protein: Leucine zipper putative tumor suppressor 3

Source gene: LZTS3

Class: DEG_APCC_DBOX_1

Location: 220:228

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9084

ASA_SCORE: 64.9111

COIL: 0.8958

CONS_SCORE: 0.6295

DSS_SCORE: 0.5082

HELIX: 0.0526

FCONS_SCORE: 1.1879

RIG_SCORE: 0.6391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L224I	TCGA-AP-A059	UCEC	TCGA	GRNSLTSLP	DEG_APCC_DBOX_1	0.7174
p.L224I	DO41361	UCEC	ICGC	GRNSLTSLP	DEG_APCC_DBOX_1	0.7174
p.T225K	DO229026	LICA	ICGC	GRNSLTSLP	DEG_APCC_DBOX_1	0.6195
p.G220R	SIDM00357	Small Cell Lung Carcinoma	GDSC	GRNSLTSLP	DEG_APCC_DBOX_1	0.6457
p.G220R	ACH-002193	Lung Cancer	CCLE	GRNSLTSLP	DEG_APCC_DBOX_1	0.6457
p.G220R	RERF-LC-FM	lung	COSMIC	GRNSLTSLP	DEG_APCC_DBOX_1	0.6457
p.S232P	DBTRG-05MG	central_nervous_system	COSMIC	GRNSLTSLP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60299	Leucine zipper putative tumor suppressor 3	DEG_APCC_DBOX_1	220:228	GRNSLTSLP	APC,CDC20,FZR1	0.9084	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons