DegronMD

Uniprot ID: O60299

Source protein: Leucine zipper putative tumor suppressor 3

Source gene: LZTS3

Class: DEG_SCF_TRCP1_1

Location: 218:223

E3 ligase: BTRC

DEGRON score: 0.9945

ASA_SCORE: 69.2833

COIL: 0.8708

CONS_SCORE: 0.6058

DSS_SCORE: 0.5638

HELIX: 0.0807

FCONS_SCORE: 1.0646

RIG_SCORE: 0.6073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A209V	SIDM01943	Colorectal Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.0833
p.A209V	SIDM00681	Colorectal Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.0833
p.A209V	ACH-000252	Colon/Colorectal Cancer	CCLE	DSGRNS	DEG_SCF_TRCP1_1	0.0833
p.A209V	LS-1034	large_intestine	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	0.0833
p.G220R	SIDM00357	Small Cell Lung Carcinoma	GDSC	DSGRNS	DEG_SCF_TRCP1_1	0.7568
p.G220R	ACH-002193	Lung Cancer	CCLE	DSGRNS	DEG_SCF_TRCP1_1	0.7568
p.G220R	RERF-LC-FM	lung	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	0.7568
p.S232P	DBTRG-05MG	central_nervous_system	COSMIC	DSGRNS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SCF_TRCP1_1	219:224	DSGRNS	BTRC	0.9995	More...
Q9Y250	Leucine zipper putative tumor suppressor 1	DEG_SCF_TRCP1_1	173:178	DSGRNS	BTRC	0.9975	More...
O60299	Leucine zipper putative tumor suppressor 3	DEG_SCF_TRCP1_1	218:223	DSGRNS	BTRC	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons