DegronMD

Uniprot ID: Q9BRK4

Source protein: Leucine zipper putative tumor suppressor 2

Source gene: LZTS2

Class: DEG_SCF_TRCP1_1

Location: 272:278

E3 ligase: BTRC

DEGRON score: 0.9986

ASA_SCORE: 74.8857

COIL: 0.8997

CONS_SCORE: 0.7267

DSS_SCORE: 0.7667

HELIX: 0.0689

FCONS_SCORE: 1.4444

RIG_SCORE: 0.5182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R262Q	TCGA-AP-A0LJ	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.0556
p.R262Q	TCGA-DK-AA6U	BLCA	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.0556
p.R262Q	DO219008	BLCA	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.0556
p.R262Q	DO42145	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.0556
p.L285I	TCGA-AP-A1DK	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.1389
p.L285I	DO42033	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.1389
p.R275W	TCGA-DF-A2KU	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.7523
p.R275W	DO218693	GACA	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.7523
p.R275W	DO223286	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.7523
p.P268S	TCGA-DI-A1BU	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.2222
p.P268S	DO42023	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.2222
p.H270N	TCGA-EE-A2M7	SKCM	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.2778
p.H270N	DO37847	SKCM	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.2778
p.P265L	TCGA-EY-A215	UCEC	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.1389
p.P265L	DO42665	UCEC	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.1389
p.S279N	TCGA-IB-7651	PAAD	TCGA	DSGRSSS	DEG_SCF_TRCP1_1	0.3056
p.S279N	DO46657	PAAD	ICGC	DSGRSSS	DEG_SCF_TRCP1_1	0.3056
p.T266I	SIDM01439	Hepatocellular Carcinoma	GDSC	DSGRSSS	DEG_SCF_TRCP1_1	0.1667
p.T266I	ACH-000537	Liver Cancer	CCLE	DSGRSSS	DEG_SCF_TRCP1_1	0.1667
p.L285P	ACH-000505	Sarcoma	CCLE	DSGRSSS	DEG_SCF_TRCP1_1	0.1389
p.L285P	RKN	ovary	COSMIC	DSGRSSS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SCF_TRCP1_1	272:278	DSGRSSS	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons