DegronMD

Uniprot ID: Q7LBE3

Source protein: Solute carrier family 26 member 9

Source gene: SLC26A9

Class: DEG_SPOP_SBC_1

Location: 629:633

E3 ligase: SPOP

DEGRON score: 0.9618

ASA_SCORE: 81.3

COIL: 0.9418

CONS_SCORE: 0.3356

DSS_SCORE: 0.691

HELIX: 0.039

FCONS_SCORE: 0.9853

RIG_SCORE: 0.5499

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A643T	TCGA-A5-A1OF	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	TCGA-AX-A2HA	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	TCGA-FI-A2D0	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	DO42568	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	DO43891	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	DO42504	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	SIDM00541	Colorectal Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	ACH-000926	Colon/Colorectal Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643T	HT55	large_intestine	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.S623Y	TCGA-AA-A00N	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	0.1667
p.S623Y	DO9876	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1667
p.P629T	TCGA-CK-6746	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	0.7031
p.P629T	DO7938	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	0.7031
p.A643D	TCGA-DX-A6YV	SARC	TCGA	PDSSS	DEG_SPOP_SBC_1	0.0556
p.A643D	DO220011	SARC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.P629S	TCGA-EE-A2GC	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	0.6752
p.P629S	DO37839	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	0.6752
p.S631R	DO222849	COCA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.7427
p.P629L	DO222904	MELA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.7582
p.P634S	DO218844	SKCA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.3056
p.S621R	DO229253	THCA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1111
p.V622L	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.V622L	SIDM00820	Kidney Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.V622L	SIDM01118	Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.V622L	SIDM01064	Hodgkin's Lymphoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.V622L	SIDM00976	Melanoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.V622M	SIDM00846	Cervical Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.V622M	HeLa	cervix	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.S642C	SIDM00799	Glioblastoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.0833
p.S642C	ACH-000558	Brain Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	0.0833
p.S642C	A172	central_nervous_system	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.0833
p.Q636K	SIDM00783	Colorectal Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.25
p.Q636K	ACH-000971	Colon/Colorectal Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	0.25
p.Q636K	HCT-116	large_intestine	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00507	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y	DEG_SPOP_SBC_1	977:981	PDSSS	SPOP	0.9861	More...
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	269:273	PDSSS	SPOP	0.935	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	1863:1867	PDSSS	SPOP	0.902	More...
P23760	Paired box protein Pax-3	DEG_SPOP_SBC_1	348:352	PDSSS	SPOP	0.9277	More...
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	83:87	PDSSS	SPOP	0.9539	More...
P48553	Trafficking protein particle complex subunit 10	DEG_SPOP_SBC_1	1199:1203	PDSSS	SPOP	0.9812	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	748:752	PDSSS	SPOP	0.8579	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	310:314	PDSSS	SPOP	0.9763	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	260:264	PDSSS	SPOP	0.9877	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	1166:1170	PDSSS	SPOP	0.9878	More...
Q15642	Cdc42-interacting protein 4	DEG_SPOP_SBC_1	498:502	PDSSS	SPOP	0.9962	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	515:519	PDSSS	SPOP	0.9977	More...
Q7LBE3	Solute carrier family 26 member 9	DEG_SPOP_SBC_1	629:633	PDSSS	SPOP	0.9618	More...
Q7Z333	Probable helicase senataxin	DEG_SPOP_SBC_1	1485:1489	PDSSS	SPOP	0.8761	More...
Q86VZ4	Low-density lipoprotein receptor-related protein 11	DEG_SPOP_SBC_1	417:421	PDSSS	SPOP	0.9592	More...
Q8N441	Fibroblast growth factor receptor-like 1	DEG_SPOP_SBC_1	129:133	PDSSS	SPOP	0.8851	More...
Q8TE77	Protein phosphatase Slingshot homolog 3	DEG_SPOP_SBC_1	152:156	PDSSS	SPOP	0.7282	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	567:571	PDSSS	SPOP	0.9916	More...
Q93008	Probable ubiquitin carboxyl-terminal hydrolase FAF-X	DEG_SPOP_SBC_1	976:980	PDSSS	SPOP	0.9934	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	302:306	PDSSS	SPOP	0.9992	More...
Q9BWT3	Poly	DEG_SPOP_SBC_1	712:716	PDSSS	SPOP	0.9943	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	86:90	PDSSS	SPOP	0.9916	More...
Q9NWZ3	Interleukin-1 receptor-associated kinase 4	DEG_SPOP_SBC_1	148:152	PDSSS	SPOP	0.9855	More...
Q9NXG0	Centlein	DEG_SPOP_SBC_1	1396:1400	PDSSS	SPOP	0.9251	More...
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	DEG_SPOP_SBC_1	945:949	PDSSS	SPOP	0.9951	More...
P31267	Homeobox protein Hox-A6	DEG_SPOP_SBC_1	113:117	PDSSS	SPOP	0.545	More...
Q2T9L4	Inhibitory synaptic factor 1	DEG_SPOP_SBC_1	157:161	PDSSS	SPOP	0.9993	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	170:174	PDSSS	SPOP	0.9796	More...
Q8TA94	Zinc finger protein 563	DEG_SPOP_SBC_1	263:267	PDSSS	SPOP	0.9213	More...
P13985	Putative HTLV-1-related endogenous sequence	DEG_SPOP_SBC_1	139:143	PDSSS	SPOP	0.8586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSSS

Degron related mutations and impact score

Drug responses associated with SLC26A9 mutations

All proteins holding degron of PDSSS