DegronMD - Q9NXG0(CNTLN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1391R	TCGA-A8-A07W	BRCA	TCGA	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1944
p.K1391R	DO1297	BRCA	ICGC	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1944
p.D323Y	TCGA-AX-A1CE	UCEC	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.2222
p.D323Y	DO42280	UCEC	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.2222
p.Q319P	TCGA-AX-A2HC	UCEC	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1111
p.Q319P	DO41572	UCEC	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1111
p.K329N	TCGA-AX-A2HC	UCEC	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.5806
p.L317R	TCGA-D7-6528	STAD	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.L317R	DO38547	STAD	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.L317R	SIDM02010	Esophageal Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.Y1398F	TCGA-DK-A3IQ	BLCA	TCGA	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation altering degron motif	0.7528
p.Y1398F	DO445	BLCA	ICGC	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation altering degron motif	0.7528
p.R1406T	TCGA-EK-A2RC	CESC	TCGA	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1667
p.R1406T	DO49945	CESC	ICGC	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1667
p.K1392N	TCGA-MV-A51V	BLCA	TCGA	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2222
p.K1392N	DO474	BLCA	ICGC	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.2222
p.V1388M	DO229005	COCA	ICGC	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.1111
p.L317P	DO233854	GACA	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.E330Q	DO25104	LUAD	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.5633
p.V1395I	DO231124	LUSC	ICGC	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation rewiring degron network	0.3056
p.K320M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation substituting flanking lysine	0.25
p.K320M	ACH-002238	Leukemia	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation substituting flanking lysine	0.25
p.K320M	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation substituting flanking lysine	0.25
p.Y338H	SIDM01186	Breast Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.25
p.Y338H	ACH-000554	Breast Cancer	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.25
p.Y338H	UACC-893	breast	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.25
p.R328W	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.8634
p.R328W	ACH-000305	Esophageal Cancer	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.8634
p.R328W	EC-GI-10	oesophagus	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.8634
p.S342I	SIDM00927	Small Cell Lung Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1389
p.S342I	ACH-000871	Lung Cancer	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1389
p.S342I	NCI-H510A	lung	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1389
p.S1398L	ACH-000965	Endometrial/Uterine Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	1396:1400	Mutation altering degron motif	0.7667

Kaplan plot for CNTLN in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNTLN

UniProt ID: Q9NXG0

Entrez ID: 54875

Protein name: Centlein (Centrosomal protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CNTLN in