DegronMD

Uniprot ID: Q9NXG0

Source protein: Centlein

Source gene: CNTLN

Class: DEG_APCC_DBOX_1

Location: 327:335

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6488

ASA_SCORE: 103.8

COIL: 0.0139

CONS_SCORE: 0.5289

DSS_SCORE: 0.2017

HELIX: 0.9859

FCONS_SCORE: 1.3023

RIG_SCORE: 0.8491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D323Y	TCGA-AX-A1CE	UCEC	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	0.2222
p.D323Y	DO42280	UCEC	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	0.2222
p.Q319P	TCGA-AX-A2HC	UCEC	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	0.1111
p.Q319P	DO41572	UCEC	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	0.1111
p.K329N	TCGA-AX-A2HC	UCEC	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	0.5806
p.L317R	TCGA-D7-6528	STAD	TCGA	VRKELQELQ	DEG_APCC_DBOX_1	0.0556
p.L317R	DO38547	STAD	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	0.0556
p.L317R	SIDM02010	Esophageal Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	0.0556
p.L317P	DO233854	GACA	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	0.0556
p.E330Q	DO25104	LUAD	ICGC	VRKELQELQ	DEG_APCC_DBOX_1	0.5633
p.K320M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	0.25
p.K320M	ACH-002238	Leukemia	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	0.25
p.K320M	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	0.25
p.Y338H	SIDM01186	Breast Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	0.25
p.Y338H	ACH-000554	Breast Cancer	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	0.25
p.Y338H	UACC-893	breast	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	0.25
p.R328W	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	0.8634
p.R328W	ACH-000305	Esophageal Cancer	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	0.8634
p.R328W	EC-GI-10	oesophagus	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	0.8634
p.S342I	SIDM00927	Small Cell Lung Carcinoma	GDSC	VRKELQELQ	DEG_APCC_DBOX_1	0.1389
p.S342I	ACH-000871	Lung Cancer	CCLE	VRKELQELQ	DEG_APCC_DBOX_1	0.1389
p.S342I	NCI-H510A	lung	COSMIC	VRKELQELQ	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXG0	Centlein	DEG_APCC_DBOX_1	327:335	VRKELQELQ	APC,CDC20,FZR1	0.6488	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons