DegronMD - Q12947(FOXF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q114R	TCGA-55-8301	LUAD	TCGA	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.Q114R	DO24682	LUAD	ICGC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.T122M	TCGA-BR-4362	STAD	TCGA	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation altering degron motif	0.6312
p.T122M	DO38336	STAD	ICGC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation altering degron motif	0.6312
p.F129L	TCGA-DK-A3IQ	BLCA	TCGA	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.2778
p.F129L	DO445	BLCA	ICGC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.2778
p.P32A	DO233044	GACA	ICGC	PETTS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0556
p.A33P	DO233867	GACA	ICGC	PETTS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0833
p.P69L	DO50970	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	57:61	Mutation rewiring degron network	0.1111
p.A300V	DO232846	NACA	ICGC	PDSSS	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.0556
p.A36T	DO229259	THCA	ICGC	PETTS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1667
p.Y308H	DO229272	THCA	ICGC	PDSSS	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.2778
p.A132T	SIDM00993	Plasma Cell Myeloma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.A132T	SIDM00231	Kidney Carcinoma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.A132T	SIDM01735	Biliary Tract Carcinoma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.A132T	NCC010	kidney	COSMIC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.A132T	AMO-1	haematopoietic and lymphoid tissue	COSMIC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.E43K	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PETTS	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.591
p.A132S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.A132S	ACH-000914	Lymphoma	CCLE	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.A132S	HT	haematopoietic and lymphoid tissue	COSMIC	KRLTLSEIY	DEG_APCC_DBOX_1	119:127	Mutation rewiring degron network	0.1944
p.A68V	SIDM00493	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	57:61	Mutation rewiring degron network	0.1389
p.G309R	SIDM00960	Colorectal Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	310:314	Mutation rewiring degron network	0.3056
p.S49L	ACH-000007	Colon/Colorectal Cancer	CCLE	PETTS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.25
p.S49L	ACH-000007	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	57:61	Mutation rewiring degron network	0.1111

Kaplan plot for FOXF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXF2

UniProt ID: Q12947

Entrez ID: 2295

Protein name: Forkhead box protein F2 (Forkhead-related activator 2) (FREAC-2) (Forkhead-related protein FKHL6) (Forkhead-related transcription factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXF2 in