DegronMD

Uniprot ID: Q12947

Source protein: Forkhead box protein F2

Source gene: FOXF2

Class: DEG_APCC_DBOX_1

Location: 119:127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6763

ASA_SCORE: 48.7444

COIL: 0.3042

CONS_SCORE: 0.7955

DSS_SCORE: 0.0736

HELIX: 0.5654

FCONS_SCORE: 1.2026

RIG_SCORE: 0.8679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q114R	TCGA-55-8301	LUAD	TCGA	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.Q114R	DO24682	LUAD	ICGC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.T122M	TCGA-BR-4362	STAD	TCGA	KRLTLSEIY	DEG_APCC_DBOX_1	0.6312
p.T122M	DO38336	STAD	ICGC	KRLTLSEIY	DEG_APCC_DBOX_1	0.6312
p.F129L	TCGA-DK-A3IQ	BLCA	TCGA	KRLTLSEIY	DEG_APCC_DBOX_1	0.2778
p.F129L	DO445	BLCA	ICGC	KRLTLSEIY	DEG_APCC_DBOX_1	0.2778
p.A132T	SIDM00993	Plasma Cell Myeloma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.A132T	SIDM00231	Kidney Carcinoma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.A132T	SIDM01735	Biliary Tract Carcinoma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.A132T	NCC010	kidney	COSMIC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.A132T	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.A132S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.A132S	ACH-000914	Lymphoma	CCLE	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944
p.A132S	HT	haematopoietic_and_lymphoid_tissue	COSMIC	KRLTLSEIY	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12947	Forkhead box protein F2	DEG_APCC_DBOX_1	119:127	KRLTLSEIY	APC,CDC20,FZR1	0.6763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons