DegronMD - Q7LBE3(SLC26A9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A643T	TCGA-A5-A1OF	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	TCGA-AX-A2HA	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	TCGA-FI-A2D0	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	DO42568	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	DO43891	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	DO42504	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	SIDM00541	Colorectal Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	ACH-000926	Colon/Colorectal Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643T	HT55	large intestine	COSMIC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.S623Y	TCGA-AA-A00N	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1667
p.S623Y	DO9876	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1667
p.P629T	TCGA-CK-6746	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7031
p.P629T	DO7938	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7031
p.A643D	TCGA-DX-A6YV	SARC	TCGA	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.A643D	DO220011	SARC	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0556
p.P629S	TCGA-EE-A2GC	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.6752
p.P629S	DO37839	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.6752
p.S631R	DO222849	COCA	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7427
p.P629L	DO222904	MELA	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation altering degron motif	0.7582
p.P634S	DO218844	SKCA	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.3056
p.S621R	DO229253	THCA	ICGC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1111
p.V622L	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.V622L	SIDM00820	Kidney Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.V622L	SIDM01118	Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.V622L	SIDM01064	Hodgkin's Lymphoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.V622L	SIDM00976	Melanoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.V622M	SIDM00846	Cervical Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.V622M	HeLa	cervix	COSMIC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.1389
p.S642C	SIDM00799	Glioblastoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0833
p.S642C	ACH-000558	Brain Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0833
p.S642C	A172	central nervous system	COSMIC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.0833
p.Q636K	SIDM00783	Colorectal Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.25
p.Q636K	ACH-000971	Colon/Colorectal Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.25
p.Q636K	HCT-116	large intestine	COSMIC	PDSSS	DEG_SPOP_SBC_1	629:633	Mutation rewiring degron network	0.25

Kaplan plot for SLC26A9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC26A9

UniProt ID: Q7LBE3

Entrez ID: 115019

Protein name: Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC26A9 in