DegronMD

Uniprot ID: Q6VAB6

Source protein: Kinase suppressor of Ras 2

Source gene: KSR2

Class: DEG_SCF_FBW7_1

Location: 258:264

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 113.6714

COIL: 0.9774

CONS_SCORE: 0.3488

DSS_SCORE: 0.7931

HELIX: 0.0097

FCONS_SCORE: 0.9943

RIG_SCORE: 0.5771

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R263H	TCGA-A6-4107	COAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.7133
p.R263H	TCGA-BR-4184	STAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.7133
p.R263H	TCGA-FI-A2D5	UCEC	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.7133
p.R263H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.7133
p.R263C	TCGA-AA-A01R	COAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.719
p.R263C	TCGA-B5-A5OC	UCEC	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.719
p.R263C	DO7934	COAD	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.719
p.R263C	DO52405	UCEC	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.719
p.R263C	ACH-000007	Colon/Colorectal Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.719
p.R263C	LS-513	large_intestine	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.719
p.R253Q	TCGA-AJ-A2QO	UCEC	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.1944
p.R253Q	TCGA-HT-8563	LGG	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.1944
p.T270I	TCGA-BF-A1PX	SKCM	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.6111
p.T270I	DO51236	SKCM	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.6111
p.A257V	TCGA-BR-7851	STAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.3056
p.P261L	TCGA-DU-5870	LGG	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.7582
p.P261S	TCGA-EE-A29G	SKCM	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.6752
p.S251L	TCGA-W3-A828	SKCM	TCGA	VRTPPRT	DEG_SCF_FBW7_1	0.1389
p.P258L	DO234269	ESAD	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.7582
p.R259H	DO233864	GACA	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.7133
p.R259H	DO228142	PBCA	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.7133
p.P265S	DO220907	MELA	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.3056
p.G260E	DO37519	SKCM	ICGC	VRTPPRT	DEG_SCF_FBW7_1	0.7199
p.P263L	SIDM01943	Colorectal Carcinoma	GDSC	VRTPPRT	DEG_SCF_FBW7_1	0.7582
p.P248S	SIDM00660	Colorectal Carcinoma	GDSC	VRTPPRT	DEG_SCF_FBW7_1	0.0556
p.P248S	LS-411N	large_intestine	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.0556
p.P264L	SIDM00150	Colorectal Carcinoma	GDSC	VRTPPRT	DEG_SCF_FBW7_1	0.7582
p.P264L	KM12	large_intestine	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.7582
p.V268L	ACH-000250	Kidney Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.2222
p.V268L	KMRC-20	kidney	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.2222
p.R255W	ACH-000383	Esophageal Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.25
p.R255W	ACH-000694	Esophageal Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.25
p.R255W	OE33	oesophagus	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.25
p.P262L	ACH-000915	Skin Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.6471
p.P262L	IPC-298	skin	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.6471
p.I267L	ACH-000987	Skin Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.25
p.I267L	Mewo	skin	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.25
p.P250T	ACH-002272	Lymphoma	CCLE	VRTPPRT	DEG_SCF_FBW7_1	0.1111
p.P250T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTPPRT

Degron related mutations and impact score

Drug responses associated with KSR2 mutations

All proteins holding degron of VRTPPRT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VAB6	Kinase suppressor of Ras 2	DEG_SCF_FBW7_1	258:264	VRTPPRT	FBXW7	0.9959	More...