DegronMD

Uniprot ID: Q6VAB6

Source protein: Kinase suppressor of Ras 2

Source gene: KSR2

Class: ITCH

Location: 486:489

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9326

ASA_SCORE: 92.55

COIL: 0.9025

CONS_SCORE: 0.3353

DSS_SCORE: 0.5082

HELIX: 0.0582

FCONS_SCORE: 0.9612

RIG_SCORE: 0.6931

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q496E	TCGA-74-6575	GBM	TCGA	PPRY	ITCH	0.1389
p.P476L	TCGA-A5-A0G2	UCEC	TCGA	PPRY	ITCH	0.0556
p.P476L	TCGA-D3-A2JP	SKCM	TCGA	PPRY	ITCH	0.0556
p.P476L	DO222662	MELA	ICGC	PPRY	ITCH	0.0556
p.P476L	DO47407	SKCM	ICGC	PPRY	ITCH	0.0556
p.P476L	DO41235	UCEC	ICGC	PPRY	ITCH	0.0556
p.R488H	TCGA-B5-A3FC	UCEC	TCGA	PPRY	ITCH	0.7133
p.P482S	TCGA-CG-4437	STAD	TCGA	PPRY	ITCH	0.2222
p.P482S	TCGA-FW-A3R5	SKCM	TCGA	PPRY	ITCH	0.2222
p.D478N	TCGA-EE-A2MF	SKCM	TCGA	PPRY	ITCH	0.1111
p.P499T	TCGA-FS-A1ZB	SKCM	TCGA	PPRY	ITCH	0.0556
p.R484Q	TCGA-FW-A3R5	SKCM	TCGA	PPRY	ITCH	0.2778
p.R484Q	DO222363	MELA	ICGC	PPRY	ITCH	0.2778
p.K485T	TCGA-L5-A4OT	ESCA	TCGA	PPRY	ITCH	0.3056
p.K485T	DO233165	GACA	ICGC	PPRY	ITCH	0.3056
p.R484W	DO222769	COCA	ICGC	PPRY	ITCH	0.2778
p.T497M	DO234401	ESAD	ICGC	PPRY	ITCH	0.5556
p.H493Q	DO229031	LICA	ICGC	PPRY	ITCH	0.2222
p.P483R	DO219261	PRAD	ICGC	PPRY	ITCH	0.25
p.S488F	DO51761	STAD	ICGC	PPRY	ITCH	0.7982
p.T496A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPRY	ITCH	0.1389
p.T496A	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPRY	ITCH	0.1389
p.D487N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPRY	ITCH	0.6932
p.D487N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPRY	ITCH	0.6932
p.P499L	ACH-000553	Lung Cancer	CCLE	PPRY	ITCH	0.0556
p.N480S	ACH-000768	Breast Cancer	CCLE	PPRY	ITCH	0.1667
p.N480S	MDA-MB-231	breast	COSMIC	PPRY	ITCH	0.1667
p.N481T	HCC1569	breast	COSMIC	PPRY	ITCH	0.1944

Drug responses associated with KSR2 mutations

All proteins holding degron of PPRY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	ITCH	717:720	PPRY	ITCH,NEDD4	0.7033	More...
O00299	Chloride intracellular channel protein 1	ITCH	90:93	PPRY	ITCH,NEDD4	0.8886	More...
O15247	Chloride intracellular channel protein 2	ITCH	96:99	PPRY	ITCH,NEDD4	0.9319	More...
O43313	ATM interactor	ITCH	287:290	PPRY	ITCH,NEDD4	0.9841	More...
O43435	T-box transcription factor TBX1	ITCH	47:50	PPRY	ITCH,NEDD4	0.9424	More...
O75208	Ubiquinone biosynthesis protein COQ9, mitochondrial	ITCH	79:82	PPRY	ITCH,NEDD4	0.8635	More...
O95793	Double-stranded RNA-binding protein Staufen homolog 1	ITCH	113:116	PPRY	ITCH,NEDD4	0.9455	More...
P05198	Eukaryotic translation initiation factor 2 subunit 1	ITCH	232:235	PPRY	ITCH,NEDD4	0.6815	More...
P21860	Receptor tyrosine-protein kinase erbB-3	ITCH	972:975	PPRY	ITCH,NEDD4	0.9993	More...
P30876	DNA-directed RNA polymerase II subunit RPB2	ITCH	81:84	PPRY	ITCH,NEDD4	0.9176	More...
P53007	Tricarboxylate transport protein, mitochondrial	ITCH	61:64	PPRY	ITCH,NEDD4	0.7489	More...
P54753	Ephrin type-B receptor 3	ITCH	438:441	PPRY	ITCH,NEDD4	0.969	More...
Q09327	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	ITCH	148:151	PPRY	ITCH,NEDD4	0.9144	More...
Q13825	Methylglutaconyl-CoA hydratase, mitochondrial	ITCH	333:336	PPRY	ITCH,NEDD4	0.5278	More...
Q14332	Frizzled-2	ITCH	189:192	PPRY	ITCH,NEDD4	0.5291	More...
Q14526	Hypermethylated in cancer 1 protein	ITCH	377:380	PPRY	ITCH,NEDD4	0.9217	More...
Q5CZC0	Fibrous sheath-interacting protein 2	ITCH	5867:5870	PPRY	ITCH,NEDD4	0.994	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	ITCH	1458:1461	PPRY	ITCH,NEDD4	0.5362	More...
Q6VAB6	Kinase suppressor of Ras 2	ITCH	486:489	PPRY	ITCH,NEDD4	0.9326	More...
Q86TB9	Protein PAT1 homolog 1	ITCH	221:224	PPRY	ITCH,NEDD4	0.9488	More...
Q8TC29	Enkurin	ITCH	24:27	PPRY	ITCH,NEDD4	0.9988	More...
Q8WUF5	RelA-associated inhibitor	ITCH	67:70	PPRY	ITCH,NEDD4	0.994	More...
Q8WWW0	Ras association domain-containing protein 5	ITCH	21:24	PPRY	ITCH,NEDD4	0.8918	More...
Q96NY7	Chloride intracellular channel protein 6	ITCH	553:556	PPRY	ITCH,NEDD4	0.9782	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	ITCH	1239:1242	PPRY	ITCH,NEDD4	0.9754	More...
Q96T58	Msx2-interacting protein	ITCH	771:774	PPRY	ITCH,NEDD4	0.7541	More...
Q99959	Plakophilin-2	ITCH	191:194	PPRY	ITCH,NEDD4	0.9964	More...
Q9H2D6	TRIO and F-actin-binding protein	ITCH	1029:1032	PPRY	ITCH,NEDD4	0.9563	More...
Q9NQL9	Doublesex- and mab-3-related transcription factor 3	ITCH	365:368	PPRY	ITCH,NEDD4	0.9917	More...
Q9NR12	PDZ and LIM domain protein 7	ITCH	101:104	PPRY	ITCH,NEDD4	0.9771	More...
Q9NU39	Forkhead box protein D4-like 1	ITCH	266:269	PPRY	ITCH,NEDD4	0.9298	More...
Q9NYQ8	Protocadherin Fat 2	ITCH	4240:4243	PPRY	ITCH,NEDD4	0.9922	More...
Q9UJV9	Probable ATP-dependent RNA helicase DDX41	ITCH	148:151	PPRY	ITCH,NEDD4	0.9995	More...
Q9ULH7	Myocardin-related transcription factor B	ITCH	871:874	PPRY	ITCH,NEDD4	0.999	More...
O15417	Trinucleotide repeat-containing gene 18 protein	ITCH	1079:1082	PPRY	ITCH,NEDD4	0.9345	More...
Q8WVE6	Transmembrane protein 171	ITCH	301:304	PPRY	ITCH,NEDD4	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPRY

Degron related mutations and impact score

Drug responses associated with KSR2 mutations

All proteins holding degron of PPRY