DegronMD - Q9NQL9(DMRT3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G356W	TCGA-05-4424	LUAD	TCGA	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356W	TCGA-05-4424	LUAD	TCGA	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.G356W	DO23672	LUAD	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356W	DO23672	LUAD	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.V254E	TCGA-25-1313	OV	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6582
p.V254E	TCGA-95-7567	LUAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6582
p.V254E	DO25564	LUAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6582
p.V254E	DO28050	OV	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6582
p.V239F	TCGA-34-5236	LUSC	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0833
p.V239F	DO26778	LUSC	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0833
p.L358V	TCGA-69-7980	LUAD	TCGA	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1944
p.L358V	TCGA-69-7980	LUAD	TCGA	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1389
p.L358V	DO23678	LUAD	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1944
p.L358V	DO23678	LUAD	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1389
p.P250T	TCGA-97-A4LX	LUAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5919
p.P250T	DO218934	LUAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5919
p.Q364R	TCGA-A6-2686	COAD	TCGA	PPRY	ITCH	365:368	Mutation rewiring degron network	0.3056
p.Q364R	DO7828	COAD	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.3056
p.R335Q	TCGA-AP-A0LM	UCEC	TCGA	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1111
p.R335Q	DO232761	PBCA	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1111
p.R335Q	DO43306	UCEC	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1111
p.R373M	TCGA-B5-A0JY	UCEC	TCGA	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1944
p.R373M	DO43041	UCEC	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1944
p.R367Q	TCGA-B5-A3FC	UCEC	TCGA	PPRY	ITCH	365:368	Mutation altering degron motif	0.6218
p.R367Q	DO41871	UCEC	ICGC	PPRY	ITCH	365:368	Mutation altering degron motif	0.6218
p.G441W	TCGA-BF-A1PZ	SKCM	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1667
p.G441W	DO50279	SKCM	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1667
p.R335G	TCGA-CF-A47X	BLCA	TCGA	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1111
p.R335G	DO44042	BLCA	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1111
p.R459K	TCGA-CM-6678	COAD	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1667
p.R459K	DO10220	COAD	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1667
p.E458K	TCGA-CN-A641	HNSC	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1944
p.E458K	DO44436	HNSC	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1944
p.P438H	TCGA-DU-7298	LGG	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.0833
p.P438H	DO22679	LGG	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.0833
p.P351S	TCGA-EE-A2MC	SKCM	TCGA	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation altering degron motif	0.6752
p.P351S	DO37559	SKCM	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation altering degron motif	0.6752
p.V266M	TCGA-FI-A2D0	UCEC	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0556
p.V266M	DO43891	UCEC	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0556
p.K447N	TCGA-FI-A2D5	UCEC	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation altering degron motif	0.6918
p.K447N	DO41331	UCEC	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation altering degron motif	0.6918
p.P337Q	TCGA-FS-A1ZJ	SKCM	TCGA	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1667
p.P337Q	DO37956	SKCM	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1667
p.S446L	TCGA-FZ-5921	PAAD	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.3056
p.S446L	DO51688	PAAD	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.3056
p.T375A	TCGA-G3-AAV4	LIHC	TCGA	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1389
p.T375A	DO52298	LIHC	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1389
p.T265M	TCGA-G4-6586	COAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation blocking phosphorylation signal	0.5278
p.T265M	DO9698	COAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation blocking phosphorylation signal	0.5278
p.T265M	DO233685	GACA	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation blocking phosphorylation signal	0.5278
p.A355V	TCGA-GN-A266	SKCM	TCGA	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.2778
p.A355V	TCGA-GN-A266	SKCM	TCGA	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0556
p.A355V	DO37432	SKCM	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.2778
p.A355V	DO37432	SKCM	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0556
p.F259L	TCGA-QG-A5Z2	COAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.25
p.F259L	DO44096	COAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.25
p.R367W	DO225249	BRCA	ICGC	PPRY	ITCH	365:368	Mutation altering degron motif	0.7523
p.I437M	DO224847	BRCA	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.0556
p.I437M	DO227473	BRCA	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.0556
p.G356V	DO229016	COCA	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356V	DO229016	COCA	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.G356V	DO234285	ESAD	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356V	DO234285	ESAD	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.G356V	DO229353	LAML	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356V	DO229353	LAML	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.G356V	DO231140	LAML	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356V	DO231140	LAML	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.G356V	DO230545	LUSC	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356V	DO230545	LUSC	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.G356V	DO231051	LUSC	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.25
p.G356V	DO231051	LUSC	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.0833
p.D439H	DO229003	COCA	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1111
p.T452I	DO234230	ESAD	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation altering degron motif	0.7078
p.T339M	DO218243	GACA	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.2222
p.S244I	DO231988	LICA	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.2222
p.R373S	DO229028	LICA	ICGC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1944
p.T339K	DO231669	LINC	ICGC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.2222
p.P264L	DO220906	MELA	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1111
p.V266E	SIDM00629	Breast Carcinoma	GDSC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0556
p.V266E	ACH-000573	Breast Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0556
p.R341K	SIDM01156	Small Cell Lung Carcinoma	GDSC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.2778
p.R341K	ACH-000890	Lung Cancer	CCLE	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.2778
p.R341K	SW1271	lung	COSMIC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.2778
p.P251S	SIDM00789	Colorectal Carcinoma	GDSC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5641
p.P251S	ACH-000997	Colon/Colorectal Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5641
p.P251S	ACH-001061	Colon/Colorectal Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5641
p.P251S	HCT-15	large intestine	COSMIC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5641
p.M371T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.25
p.M371T	ACH-002256	Leukemia	CCLE	PPRY	ITCH	365:368	Mutation rewiring degron network	0.25
p.M371T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.25
p.L252V	SIDM00265	Ewing's Sarcoma	GDSC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6765
p.L252V	ACH-002104	Bone Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6765
p.L252V	ES3	bone	COSMIC	NRPPLEVLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6765
p.I437T	SIDM00487	Colorectal Carcinoma	GDSC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.0556
p.I437T	ACH-000963	Colon/Colorectal Cancer	CCLE	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.0556
p.I437T	CCK-81	large intestine	COSMIC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.0556
p.P366L	SIDM00150	Colorectal Carcinoma	GDSC	PPRY	ITCH	365:368	Mutation altering degron motif	0.7582
p.P366L	ACH-000969	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	365:368	Mutation altering degron motif	0.7582
p.P366L	KM12	large intestine	COSMIC	PPRY	ITCH	365:368	Mutation altering degron motif	0.7582
p.D440N	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1389
p.D440N	ACH-000888	Lung Cancer	CCLE	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1389
p.D440N	NCI-H1793	lung	COSMIC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	447:453	Mutation rewiring degron network	0.1389
p.P361S	SIDM01611	Endometrial Carcinoma	GDSC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1111
p.P361S	SIDM01611	Endometrial Carcinoma	GDSC	PPRY	ITCH	365:368	Mutation rewiring degron network	0.2222
p.P361S	ACH-000996	Endometrial/Uterine Cancer	CCLE	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1111
p.P361S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPRY	ITCH	365:368	Mutation rewiring degron network	0.2222
p.S347T	SIDM01525	Acute Myeloid Leukemia	GDSC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation altering degron motif	0.7116
p.T375N	ACH-002061	Leukemia	CCLE	PPRY	ITCH	365:368	Mutation rewiring degron network	0.1389
p.V336A	ACH-002275	Leukemia	CCLE	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1389
p.V336A	MN-60	haematopoietic and lymphoid tissue	COSMIC	SADSSNVVPSP	DEG_COP1_1	343:353	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMRT3

UniProt ID: Q9NQL9

Entrez ID: 58524

Protein name: Doublesex- and mab-3-related transcription factor 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMRT3 in