DegronMD

Uniprot ID: Q9NQL9

Source protein: Doublesex- and mab-3-related transcription factor 3

Source gene: DMRT3

Class: DEG_APCC_DBOX_1

Location: 248:256

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9253

ASA_SCORE: 68.1333

COIL: 0.4253

CONS_SCORE: 0.7013

DSS_SCORE: 0.242

HELIX: 0.5669

FCONS_SCORE: 1.1876

RIG_SCORE: 0.8016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V254E	TCGA-25-1313	OV	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	0.6582
p.V254E	TCGA-95-7567	LUAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	0.6582
p.V254E	DO25564	LUAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.6582
p.V254E	DO28050	OV	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.6582
p.V239F	TCGA-34-5236	LUSC	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	0.0833
p.V239F	DO26778	LUSC	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.0833
p.P250T	TCGA-97-A4LX	LUAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	0.5919
p.P250T	DO218934	LUAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.5919
p.V266M	TCGA-FI-A2D0	UCEC	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	0.0556
p.V266M	DO43891	UCEC	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.0556
p.T265M	TCGA-G4-6586	COAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	0.5278
p.T265M	DO9698	COAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.5278
p.T265M	DO233685	GACA	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.5278
p.F259L	TCGA-QG-A5Z2	COAD	TCGA	NRPPLEVLK	DEG_APCC_DBOX_1	0.25
p.F259L	DO44096	COAD	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.25
p.S244I	DO231988	LICA	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.2222
p.P264L	DO220906	MELA	ICGC	NRPPLEVLK	DEG_APCC_DBOX_1	0.1111
p.V266E	SIDM00629	Breast Carcinoma	GDSC	NRPPLEVLK	DEG_APCC_DBOX_1	0.0556
p.V266E	ACH-000573	Breast Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	0.0556
p.P251S	SIDM00789	Colorectal Carcinoma	GDSC	NRPPLEVLK	DEG_APCC_DBOX_1	0.5641
p.P251S	ACH-000997	Colon/Colorectal Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	0.5641
p.P251S	ACH-001061	Colon/Colorectal Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	0.5641
p.P251S	HCT-15	large_intestine	COSMIC	NRPPLEVLK	DEG_APCC_DBOX_1	0.5641
p.L252V	SIDM00265	Ewing's Sarcoma	GDSC	NRPPLEVLK	DEG_APCC_DBOX_1	0.6765
p.L252V	ACH-002104	Bone Cancer	CCLE	NRPPLEVLK	DEG_APCC_DBOX_1	0.6765
p.L252V	ES3	bone	COSMIC	NRPPLEVLK	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQL9	Doublesex- and mab-3-related transcription factor 3	DEG_APCC_DBOX_1	248:256	NRPPLEVLK	APC,CDC20,FZR1	0.9253	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRPPLEVLK

Degron related mutations and impact score

Drug responses associated with DMRT3 mutations

All proteins holding degron of NRPPLEVLK