DegronMD

Uniprot ID: Q9NQL9

Source protein: Doublesex- and mab-3-related transcription factor 3

Source gene: DMRT3

Class: DEG_COP1_1

Location: 343:353

E3 ligase: COP1

DEGRON score: 0.9948

ASA_SCORE: 54.2273

COIL: 0.9051

CONS_SCORE: 0.4986

DSS_SCORE: 0.4313

HELIX: 0.0417

FCONS_SCORE: 0.9262

RIG_SCORE: 0.6652

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G356W	TCGA-05-4424	LUAD	TCGA	SADSSNVVPSP	DEG_COP1_1	0.25
p.G356W	DO23672	LUAD	ICGC	SADSSNVVPSP	DEG_COP1_1	0.25
p.L358V	TCGA-69-7980	LUAD	TCGA	SADSSNVVPSP	DEG_COP1_1	0.1944
p.L358V	DO23678	LUAD	ICGC	SADSSNVVPSP	DEG_COP1_1	0.1944
p.R335Q	TCGA-AP-A0LM	UCEC	TCGA	SADSSNVVPSP	DEG_COP1_1	0.1111
p.R335Q	DO232761	PBCA	ICGC	SADSSNVVPSP	DEG_COP1_1	0.1111
p.R335Q	DO43306	UCEC	ICGC	SADSSNVVPSP	DEG_COP1_1	0.1111
p.R335G	TCGA-CF-A47X	BLCA	TCGA	SADSSNVVPSP	DEG_COP1_1	0.1111
p.R335G	DO44042	BLCA	ICGC	SADSSNVVPSP	DEG_COP1_1	0.1111
p.P351S	TCGA-EE-A2MC	SKCM	TCGA	SADSSNVVPSP	DEG_COP1_1	0.6752
p.P351S	DO37559	SKCM	ICGC	SADSSNVVPSP	DEG_COP1_1	0.6752
p.P337Q	TCGA-FS-A1ZJ	SKCM	TCGA	SADSSNVVPSP	DEG_COP1_1	0.1667
p.P337Q	DO37956	SKCM	ICGC	SADSSNVVPSP	DEG_COP1_1	0.1667
p.A355V	TCGA-GN-A266	SKCM	TCGA	SADSSNVVPSP	DEG_COP1_1	0.2778
p.A355V	DO37432	SKCM	ICGC	SADSSNVVPSP	DEG_COP1_1	0.2778
p.G356V	DO229016	COCA	ICGC	SADSSNVVPSP	DEG_COP1_1	0.25
p.G356V	DO234285	ESAD	ICGC	SADSSNVVPSP	DEG_COP1_1	0.25
p.G356V	DO229353	LAML	ICGC	SADSSNVVPSP	DEG_COP1_1	0.25
p.G356V	DO231140	LAML	ICGC	SADSSNVVPSP	DEG_COP1_1	0.25
p.G356V	DO230545	LUSC	ICGC	SADSSNVVPSP	DEG_COP1_1	0.25
p.G356V	DO231051	LUSC	ICGC	SADSSNVVPSP	DEG_COP1_1	0.25
p.T339M	DO218243	GACA	ICGC	SADSSNVVPSP	DEG_COP1_1	0.2222
p.T339K	DO231669	LINC	ICGC	SADSSNVVPSP	DEG_COP1_1	0.2222
p.R341K	SIDM01156	Small Cell Lung Carcinoma	GDSC	SADSSNVVPSP	DEG_COP1_1	0.2778
p.R341K	ACH-000890	Lung Cancer	CCLE	SADSSNVVPSP	DEG_COP1_1	0.2778
p.R341K	SW1271	lung	COSMIC	SADSSNVVPSP	DEG_COP1_1	0.2778
p.P361S	SIDM01611	Endometrial Carcinoma	GDSC	SADSSNVVPSP	DEG_COP1_1	0.1111
p.P361S	ACH-000996	Endometrial/Uterine Cancer	CCLE	SADSSNVVPSP	DEG_COP1_1	0.1111
p.S347T	SIDM01525	Acute Myeloid Leukemia	GDSC	SADSSNVVPSP	DEG_COP1_1	0.7116
p.V336A	ACH-002275	Leukemia	CCLE	SADSSNVVPSP	DEG_COP1_1	0.1389
p.V336A	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	SADSSNVVPSP	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SADSSNVVPSP

Degron related mutations and impact score

Drug responses associated with DMRT3 mutations

All proteins holding degron of SADSSNVVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQL9	Doublesex- and mab-3-related transcription factor 3	DEG_COP1_1	343:353	SADSSNVVPSP	COP1	0.9948	More...