DegronMD

Uniprot ID: Q9NQL9

Source protein: Doublesex- and mab-3-related transcription factor 3

Source gene: DMRT3

Class: LIG_APCC_ABBAyCdc20_2

Location: 447:453

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9869

ASA_SCORE: 86.2571

COIL: 0.8464

CONS_SCORE: 0.3544

DSS_SCORE: 0.5702

HELIX: 0.0714

FCONS_SCORE: 0.7861

RIG_SCORE: 0.7463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G441W	TCGA-BF-A1PZ	SKCM	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G441W	DO50279	SKCM	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R459K	TCGA-CM-6678	COAD	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R459K	DO10220	COAD	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E458K	TCGA-CN-A641	HNSC	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E458K	DO44436	HNSC	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P438H	TCGA-DU-7298	LGG	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P438H	DO22679	LGG	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.K447N	TCGA-FI-A2D5	UCEC	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K447N	DO41331	UCEC	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.6918
p.S446L	TCGA-FZ-5921	PAAD	TCGA	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S446L	DO51688	PAAD	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I437M	DO224847	BRCA	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I437M	DO227473	BRCA	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D439H	DO229003	COCA	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T452I	DO234230	ESAD	ICGC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.7078
p.I437T	SIDM00487	Colorectal Carcinoma	GDSC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I437T	ACH-000963	Colon/Colorectal Cancer	CCLE	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I437T	CCK-81	large_intestine	COSMIC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D440N	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D440N	ACH-000888	Lung Cancer	CCLE	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D440N	NCI-H1793	lung	COSMIC	KQSIYTE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQL9	Doublesex- and mab-3-related transcription factor 3	LIG_APCC_ABBAyCdc20_2	447:453	KQSIYTE	APC,CDC20,FZR1	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons